CCG-1423 is a potent and specific inhibitor of Rho pathway signaling and activation of serum response factor (SRF) transcription.
CCG-1423 is a potent and specific inhibitor of Rho pathway signaling and activation of serum response factor (SRF) transcription. CCG-1423 inhibits SRF-driven luciferase expression in PC-3 cells following stimulation with constitutively active Gα13. Also CCG-1423 selectively inhibits DNA synthesis, proliferation and invasion of Rho-overexpressing cell lines.
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The Journal of pathology, 243(2), 208-219 (2017-07-15)
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and plays a role in prostatic carcinogenesis and prostate cancer (PCa) progression. However, the mechanisms through which UPEC promotes PCa development and progression are unclear. Cytotoxic necrotizing factor
Journal of translational medicine, 22(1), 561-561 (2024-06-13)
Fibrogenesis within ovarian endometrioma (endometrioma), mainly induced by transforming growth factor-β (TGF-β), is characterized by myofibroblast over-activation and excessive extracellular matrix (ECM) deposition, contributing to endometrioma-associated symptoms such as infertility by impairing ovarian reserve and oocyte quality. However, the precise
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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