SML0680

CYM-5541

≥98% (HPLC)

• Sinonimo/i: CYM5541, ML249, N,N-Dicyclohexyl(5-cyclopropylisoxazol-3-yl)-carboxamide, N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
• Formula empirica (notazione di Hill): C₁₉H₂₈N₂O₂
• Numero CAS: 945128-26-7
• Peso molecolare: 316.44
• UNSPSC Code: 12352211
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: N(C4CCCCC4)(C3CCCCC3)C(=O)c1n[o]c(c1)C2CC2
• InChI: 1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2
• InChI key: NDKGACIWVAOUQH-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype.

CYM-5541 is an allosteric agonist selective for the Sphingosine 1-phosphate (S1P) S1P3 receptor subtype. CYM-5541 occupies a different chemical space in the ligand binding pocket of S1P3 than S1P does, a lower hydrophobic region around transmembrane helix TM6. CYM-5541 shows great selectivity and stability with an EC₅₀ of between 72 and 132 nM compared to S1P1 EC₅₀ > 10 μM, S1P2 EC₅₀ > 50 μM, S1P4 EC₅₀ > 50 μM, and S1P5 EC₅₀ > 25 μM and no significant activities for a panel of 55 GPCRs, ion channels, and transporters.

Features and Benefits

This compound is featured on the Lysophospholipid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Parola di avvertenza: Warning
• Codici di pericolo: H302
• Avvertenze di sicurezza: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable