SML0526

EHop-016

≥98% (HPLC)

• Sinonimo/i: N4-(9-Ethyl-9H-carbazol-3-yl)-N2-[3-(4-morpholinyl)propyl]-2,4-pyrimidinediamine
• Formula empirica (notazione di Hill): C₂₅H₃₀N₆O
• Numero CAS: 1380432-32-5
• Peso molecolare: 430.55
• Numero MDL: MFCD23143628
• Codice UNSPSC: 12352200
• ID PubChem: 329825532
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 10 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCn1c2ccccc2c3cc(Nc4ccnc(NCCCN5CCOCC5)n4)ccc13
• InChI: 1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29); AFTZZRFCMOAFCR-UHFFFAOYSA-N

Descrizione

Applicazioni

EHop-016 has been used as the EHop inhibitor to study signalling diversity during Chlamydia trachomatis cell entry.[1] It has also been used as a RAC inhibitor.[2]

Azioni biochim/fisiol

EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity that inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration. EHop-016 inhibits the Rac activity of MDA-MB-231 metastatic breast cancer cells and reduces Rac-directed lamellipodia formation.

EHop-016 is a potent and specific inhibitor of Rac1 and Rac3 GTPase activity.

Caratteristiche e vantaggi

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable