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Merck
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SML0370

Sigma-Aldrich

Kartogenin

≥98% (HPLC)

Sinonimo/i:

2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN

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About This Item

Formula empirica (notazione di Hill):
C20H15NO3
Numero CAS:
4727-31-5
Peso molecolare:
317.34
Numero MDL:
MFCD00560510
Codice UNSPSC:
12352200
ID PubChem:
329825371
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Solubilità

DMSO: >15 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O

InChI

1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
SLUINPGXGFUMLL-UHFFFAOYSA-N

Azioni biochim/fisiol

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Hexamethyldisilazane reagent grade, ≥99%

Sigma-Aldrich

440191

Hexamethyldisilazane

Chitosano low molecular weight

Sigma-Aldrich

448869

Chitosano

Chun Liu et al.
Tissue engineering. Part A, 24(11-12), 990-1000 (2017-12-29)
Articular cartilage has poor capability of regeneration due to the avascular surrounding and low metabolic activity. Kartogenin (KGN), an emerging nonprotein heterocyclic compound, was screened to stimulate chondrogenic differentiation of bone mesenchymal stem cells (BMSCs). Coculturing BMSCs and chondrocytes was
Dongquan Shi et al.
ACS nano, 10(1), 1292-1299 (2016-01-13)
The regeneration of cartilage, an aneural and avascular tissue, is often compromised by its lack of innate abilities to mount a sufficient healing response. Kartogenin (KGN), a small molecular compound, can induce bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes.
Mei Zhang et al.
Cell death & disease, 8(10), e3088-e3088 (2017-10-06)
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here
Photo-cross-linked scaffold with kartogenin-encapsulated nanoparticles for cartilage regeneration
Shi D, et al.
ACS Nano, 10(1), 1292-1299 (2016)
Jianying Zhang et al.
Bone research, 2 (2014-11-25)
Tendon-bone junctions (TBJs) are frequently injured, especially in athletic settings. Healing of TBJ injuries is slow and is often repaired with scar tissue formation that compromises normal function. This study explored the feasibility of using kartogenin (KGN), a biocompound, to
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