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SML0319

Sigma-Aldrich

Caramiphen hydrochloride

≥98% (HPLC)

Sinonimo/i:

2-(Diethylamino)ethyl 1-phenylcyclopentane-1-carboxylate hydrochloride, Caramiphenium chloride salt, G 2747, Panparnit, Parpanil, Parpanit, Pentaphen, Pentaphene hydrochloride

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10 MG
214,00 €
50 MG
546,00 €

214,00 €

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10 MG
214,00 €
50 MG
546,00 €

About This Item

Formula empirica (notazione di Hill):
C18H27NO2 · HCl
Numero CAS:
125-85-9
Peso molecolare:
325.87
Numero MDL:
MFCD00242608
Codice UNSPSC:
12352200
ID PubChem:
329825324
NACRES:
NA.77

214,00 €

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Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

H2O: ≥5 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

Cl.CCN(CC)CCOC(=O)C1(CCCC1)c2ccccc2

InChI

1S/C18H27NO2.ClH/c1-3-19(4-2)14-15-21-17(20)18(12-8-9-13-18)16-10-6-5-7-11-16;/h5-7,10-11H,3-4,8-9,12-15H2,1-2H3;1H
MUPNXGNOIBYHSG-UHFFFAOYSA-N

Applicazioni

Caramiphen hydrochloride has been used to test its inhibitory effect on voltage-gated Na+ currents using the patch-clamp method.[1]

Azioni biochim/fisiol

Caramiphen hydrochloride is non-narcotic and possesses many biological functionalities of being antitussive, anticonvulsive, and neuroprotective.[1] It induces sensory block and displays less toxicity when compared to bupivacaine.[1] The local anesthetic functionality of caramiphen is mediated by its inhibitory effect on voltage-gated Na+ currents.[1]
Caramiphen is a muscarinic acetylcholine receptor antagonist.
Caramiphen is an anti-muscarinic similar to atropine; muscarinic acetylcholine receptor antagonist. Caramiphen is commonly used as a cough suppresant, but is also administered for the treatment of Parkinson′s disease. The compound has also been shown to have anti-depressant properties that may involve inhibition of G protein-coupled inwardly rectifying potassium channel GIRK.

Caratteristiche e vantaggi

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302

Classi di pericolo

Acute Tox. 4 Oral

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
096M4624V
042M4601V

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M R Domenici et al.
General pharmacology, 24(4), 991-998 (1993-07-01)
1. The effects of the non-opioid antitussives caramiphen and carbetapentane and of the anticonvulsants 5,5-diphenylhydantoin and MK 801 were tested towards hypoxia-induced electrical changes in rat hippocampal slices. 2. The incidence of appearance of hypoxia-induced epileptiform bursting was significantly decreased
G Diana et al.
Life sciences, 52(19), 1547-1557 (1993-01-01)
The effects of the non-opioid oral antitussives dextromethorphan (DM) and caramiphen (CP) were tested against the behavioural and EEG effects elicited by the N-methyl-D-aspartate (NMDA) antagonists dizocilpine (MK 801) and phencyclidine (PCP) in rats and mice. PCP (1.25-10 mg/kg i.p.)
Trond Myhrer et al.
Neurotoxicology, 34, 128-134 (2012-11-21)
Microinfusion of anticonvulsants into the perirhinal cortex through 1 guide cannula in each hemisphere only invades a small area of this seizure controlling site in rats exposed to soman. The purpose of the present study was to examine whether infusions
Yuk-Man Leung et al.
European journal of pharmacology, 746, 213-220 (2014-12-03)
The underlying mechanisms for the action of caramiphen used in local anesthesia are not well understood. The purpose of this study was to evaluate the block of caramiphen on voltage-gated Na⁺ channels and in spinal anesthesia. We investigated the effect
Ben Avi Weissman et al.
Toxicology and applied pharmacology, 232(2), 351-358 (2008-08-06)
Potent cholinesterase inhibitors (e.g., soman, sarin), induce a wide range of deleterious effects including convulsions, behavioral impairments and ultimately, death. Due to the likelihood of various scenarios of military or terrorist attacks by these and other chemical weapons, research has
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Articoli

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

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