SML0007

Cevimeline hydrochloride hemihydrate

≥95% (HPLC, NMR)

• Sinonimo/i: AF-102B, SNI-2011
• Formula empirica (notazione di Hill): C₁₀H₁₇NOS · xHCl · yH₂O
• Numero CAS: 153504-70-2
• Peso molecolare: 199.31 (anhydrous free base basis)
• Codice UNSPSC: 12352200
• ID PubChem: 329825084
• NACRES: NA.77

Proprietà

• Saggio: ≥95% (HPLC, NMR)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to tan
• Solubilità: H₂O: ≥25 mg/mL
• Ideatore: Daiichi-Sankyo
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: O.Cl.Cl.C[C@@H]1O[C@@]2(CS1)CN3CC[C@H]2CC3.C[C@@H]4O[C@@]5(CS4)CN6CC[C@H]5CC6
• InChI: 1S/2C10H17NOS.2ClH.H2O/c2*1-8-12-10(7-13-8)6-11-4-2-9(10)3-5-11;;;/h2*8-9H,2-7H2,1H3;2*1H;1H2/t2*8-,10-;;;/m11.../s1; ZSTLCHCDLIUXJE-GMLJRNIPSA-N

Descrizione

Applicazioni

Cevimeline hydrochloride hemihydrate may be used in cell signaling studies.

Azioni biochim/fisiol

Cevimeline is a muscarinic M1 and M3 receptor agonist.

Cevimeline is a muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and is used to treat the symptoms of dry mouth.

Cevimeline stimulates the peripheral muscarinic acetylcholine receptors of salivary glands and increases the concentration of Ca⁺² in parotic acini and duct cells of rats. It thus acts as therapeutic agent for xerostomia.[1][2]

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Daiichi-Sankyo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 3 Oral
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable