SBR00088

Rilpivirine

≥95% (HPLC), powder

• Sinonimo/i: 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
• Formula empirica (notazione di Hill): C₂₂H₁₈N₆
• Numero CAS: 500287-72-9
• Peso molecolare: 366.42
• Numero MDL: MFCD11046372
• Codice UNSPSC: 51101500

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: powder
• Colore: white to yellow, or beige
• Spettro attività antibiotica: viruses
• Modalità d’azione: enzyme | inhibits
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
• InChI: 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+; YIBOMRUWOWDFLG-ONEGZZNKSA-N

Descrizione

Descrizione generale

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Azioni biochim/fisiol

Nonnucleoside reverse transcriptase inhibitor (NNRTI); anti-retroviral

Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.

Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable