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SAB4503674

Sigma-Aldrich

Anti-CD40 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

B-cell surface antigen CD40, Bp50, CD40 antigen, CD40L receptor, CDw40

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 30 kDa

Reattività contro le specie

mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P25942

N° accesso UniProt

P25942

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CD40(958)

Categorie correlate

Descrizione generale

Anti-CD40 Antibody detects endogenous levels of total CD40 protein.
Cluster of differentiation 40 (CD40) is a type I transmembrane glycoprotein. It has a molecular weight of 40 ~ 50kDa and made of 277 amino acids. The CD40 gene is mapped to human chromosome 20q11-13. It has eight introns and nine exons.

Immunogeno

The antiserum was produced against synthesized peptide derived from human CD40.

Immunogen Range: 228-277

Applicazioni

Anti-CD40, C-Terminal antibody has been used in western blotting.

Azioni biochim/fisiol

Cluster of differentiation 40 (CD40) plays a major role in cellular and humoral immunity. It initiates inflammatory response to induce the progression of atherosclerosis.The CD40 pathway participates in the growth and pathogenesis of autoimmune diseases like rheumatoid arthritis (RA).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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CD40 functional gene polymorphisms and mRNA expression in rheumatoid arthritis patients from western Mexico
Roman-Fernandez IV, et al.
Genetics and molecular research : GMR (2016)
Single nucleotide polymorphisms in the CD40 gene associate with the disease susceptibility and severity in knee osteoarthritis in the Chinese Han population: a case-control study
Deng ZH, et al.
BMC Musculoskelet. Disord., 18(1), 115-115 (2017)
Yanxia Ning et al.
Metabolism: clinical and experimental, 71, 83-93 (2017-05-20)
Oxysterol sulfation plays a fundamental role in the regulation of many biological events. Its products, 25-hydroxycholesterol 3-sulfate (25HC3S) and 25-hydroxycholesterol 3, 25-disulfate (25HCDS), have been demonstrated to be potent regulators of lipid metabolism, inflammatory response, cell apoptosis, and cell survival.

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