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SAB4502713

Sigma-Aldrich

Anti-SODIUM CHANNEL-PAN antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

CIN5, HH1, SCN5A, Sodium channel protein, cardiac muscle α-subunit

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About This Item

Numero MDL:
MFCD02097413
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 227 kDa

Reattività contro le specie

mouse, human, rat

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P35498

N° accesso UniProt

Q99250

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SCN2A(6323)

Descrizione generale

Anti-SODIUM CHANNEL-PAN Antibody detects endogenous levels of total SODIUM CHANNEL-PAN protein.
The SCN5A (sodium channel protein type 5 subunit α) gene is mapped to human chromosome 3p22.2. The encoded protein is known to be localized to cardiac cells.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Sodium Channel.

Immunogen Range: 1466-1515

Azioni biochim/fisiol

SCN5A (sodium channel protein type 5 subunit α) is associated with the regulation of myocardial excitability as it conducts cardiac depolarization via inward Na+ current. Mutation in SCN5A causes retarded cardiac repolarization resulting in congenital long QT syndrome and also causes Brugada syndrome due to loss of gene function.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Vikram A
Nature Medicine, 23(3), 361-367 (2017)
Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: identification of novel LQTS3 and BrS mutations.
Ortiz-Bonnin B
Pfluegers Archiv, 468(8), 1375-1387 (2016)
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.
Burel S
The Journal of Biological Chemistry, 292(42), 17431-17448 (2017)
A common genetic variant within SCN10A modulates cardiac SCN5A expression.
van den Boogaard M
The Journal of Clinical Investigation, 124(4), 1844-1852 (2014)
Shehla U Hridi et al.
Molecular and cellular neurosciences, 95, 71-78 (2019-02-10)
Interleukin 16 (IL-16) is a cytokine that is primarily associated with CD4+ T cell function, but also exists as a multi-domain PDZ protein expressed within cerebellar and hippocampal neurons. We have previously shown that lymphocyte-derived IL-16 is neuroprotective against excitotoxicity

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.