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SAB4501464

Sigma-Aldrich

Anti-HSP60 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

60 kDa chaperonin, CH60, CPN60, HSP-60, Heat shock protein 60

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 61 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P10809

N° accesso UniProt

P10809

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... HSPD1(3329)

Descrizione generale

Anti-HSP60 antibody detects endogenous levels of total HSP60 protein.
Hsp60 (heat shock protein family D member 1) is a mitochondrial chaperone, located in the endoplasmic reticulum (ER). It is mapped to human chromosome 2q33.1.

Immunogeno

The antiserum was produced against synthesized peptide derived from human HSP60.

Immunogen Range: 511-560

Applicazioni

Anti-HSP60, C-Terminal antibody has been used in SDS/PAGE and western blot analysis.

Azioni biochim/fisiol

Hsp60 (heat shock protein family D member 1) helps to gather proteins that are imported into mitochondrial matrix. Overexpression of Hsp60 results in Behcet′s Disease (BD),Crohn′s disease, juvenile dermatomyositis (JDM), and juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis
Arya RK, et al.
Scientific Reports (2015)
OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation
Barrera M, et al.
Febs Letters, 590(19), 3309-3322 (2016)
Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria
Cheng MY, et al.
Nature, 337(6208), 620-625 (1989)
Dan A Tudorica et al.
The Journal of cell biology, 223(7) (2024-05-10)
Activation of PINK1 and Parkin in response to mitochondrial damage initiates a response that includes phosphorylation of RAB7A at Ser72. Rubicon is a RAB7A binding negative regulator of autophagy. The structure of the Rubicon:RAB7A complex suggests that phosphorylation of RAB7A
Miguel Barrera et al.
FEBS letters, 590(19), 3309-3322 (2016-09-03)
Remodeling of crista junctions (CJs) is observed in numerous human disorders and during apoptosis. The functional interplay of OPA1 and MIC60, two key players in this context, is unclear. We show that OPA1 modulates cristae morphology but is dispensable for
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