SAB4500820

Anti-THRB antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Coagulation factor II, F2, THRB
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 70 kDa
• Reattività contro le specie: human, mouse, rat
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• N° accesso NCBI: P00734
• N° accesso UniProt: P00734
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... F2(2147)

Descrizione

Descrizione generale

Anti-THRB Antibody detects endogenous levels of total THRB protein.

Thyroid hormone receptor β; (THRβ) is encoded by the gene mapped to human chromosome 3p. THRβ exist in two isoforms, THRβ1 widely expressed in brain, liver and kidney and THRβ2 expressed specifically in hypothalamus and pituitary. The encoded protein contains a C- terminal ligand-binding and dimerization domain, a DNA-binding domain and a transactivation domain.

Immunogeno

The antiserum was produced against synthesized peptide derived from human THRB.

Immunogen Range: 391-440

Azioni biochim/fisiol

Thyroid hormone receptor β (THRβ) mediates the biological functions of thyroid hormones (TH). THRβ is down-regulated in several human malignancies including papillary thyroid carcinomas (PTCs). Loss of heterozygosity in THRβ and its proximal microsatellite markers might play a crucial role in tumorigenesis and development in invasive breast cancer. Deletion of the gene coding for THRβ leads to generalized thyroid hormone resistance (GTHR). THRβ plays a vital role in the regulation of specific mRNA and miRNA in T3-induced cardiac hypertrophy and alteration of heart functions in mice.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable