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SAB4500548

Sigma-Aldrich

Anti-Adrenergic Receptor α-2A antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

α-2 adrenergic receptor subtype C10, α-2A adrenergic receptor, α-2A adrenoceptor, α-2A adrenoreceptor, α-2AAR

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About This Item

Numero MDL:
MFCD01321639
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 48 kDa

Reattività contro le specie

mouse, human, rat

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P08913

N° accesso UniProt

P08913

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ADRA2A(150)

Descrizione generale

ADRA2A (α-2A adrenergic receptor gene) is located on human chromosome 10q25. It is expressed in the caudate nucleus.
Anti-Adrenergic Receptor α-2A Antibody detects endogenous levels of total Adrenergic Receptor α-2A protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Adrenergic Receptor alpha-2A.

Immunogen Range: 331-380

Azioni biochim/fisiol

ADRA2A (α-2A adrenergic receptor gene) plays an important role in irritability, impulsivity, aggression and memory traits. Mutations in ADRA2A affects the liberation of insulin and glucose regulation. Variations in ADRA2A is linked with poor clinical prognostication. It participates in autism spectrum disorders (ASDs).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Alpha2A adrenergic receptor genetic variation contributes to hyperglycemia after myocardial infarction
Adefurin A, et al.
International Journal of Cardiology, 215, 482-486 (2016)
Abhishek Tripathi et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(13), E1659-E1668 (2015-03-17)
Recent evidence suggests that chemokine (C-X-C motif) receptor 4 (CXCR4) contributes to the regulation of blood pressure through interactions with α1-adrenergic receptors (ARs) in vascular smooth muscle. The underlying molecular mechanisms, however, are unknown. Using proximity ligation assays to visualize
Replication of genome-wide association studies (GWAS) loci for fasting plasma glucose in African-Americans
Ramos E, et al.
Diabetologia, 54(4), 783-788 (2011)
Ute A Schwinghammer et al.
Cells, 9(2) (2020-02-23)
The noradrenergic system is proposed to play a prominent role in the pathogenesis of liver fibrosis. While α1- and β-adrenergic receptors (ARs) are suggested to be involved in a multitude of profibrogenic actions, little is known about α2-AR-mediated effects and
Association between the adrenergic alpha 2A receptor gene (ADRA2A) and measures of irritability, hostility, impulsivity and memory in normal subjects
Comings DE, et al.
Psychiatric Genetics, 10(1), 39-42 (2000)
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