SAB4300517

Anti-CTTN (Ab-421) antibody produced in rabbit

affinity isolated antibody

• Sinonimo/i: Anti-EMS1 antibody produced in rabbit, Anti-FLJ34459 antibody produced in rabbit, Anti-cortactin antibody produced in rabbit
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: ~85 kDa
• Reattività contro le specie: mouse, human
• Concentrazione: 1 mg/mL
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• Isotipo: IgG
• Sequenza immunogenica: (P-I-Y-E-D)
• N° accesso NCBI: NP_005222.2
• N° accesso UniProt: Q14247
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CTTN(2017)

Descrizione

Immunogeno

Peptide sequence around aa. 419-423 (P-I-Y-E-D), according to the protein CTTN.

Caratteristiche e vantaggi

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Descrizione del bersaglio

Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

Stato fisico

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable