SAB3500977

Anti-ACE2 antibody produced in rabbit

affinity isolated antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• PM: predicted mol wt 89 kDa
• Reattività contro le specie: human
• Concentrazione: 1 mg/mL
• tecniche: ELISA: suitable; immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• N° accesso NCBI: NP_068576
• N° accesso UniProt: Q9BYF1
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ACE2(59272)

Descrizione

Descrizione generale

Angiotensin-converting enzyme-2 (ACE2), also referred as ACEH (human ACE homolog), is an integral membrane protein. It is encoded by the gene located at human chromosome Xp22.2. Ace 2 is found in variety of tissues, but the higher levels of protein is observed in vascular endothelium, lungs, heart, kidney, and testis. The protein contains a N-terminal single catalytic metallopeptidase unit, a C-terminal noncatalytic domain and a cytoplasmic tail.

Immunogeno

Antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.

Azioni biochim/fisiol

Angiotensin-converting enzyme-2 (ACE2) as a carboxypeptidase cleaves angiotensin (Ang) I to Ang 1-9. In addition, it also degrades Ang II to Ang 1–7 and plays a vital role in regulation of blood pressure. Ace 2 aids in maintaining the balance of local renin-angiotensin system (RAS). It also helps in absorbing the neutral amino acids from the intestine and the kidney. It is a cellular receptor for spike glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is known to cause coronavirus disease 2019 (COVID-19). Downregulated expression of Ace 2 has been observed in patients with cardiovascular diseases.

Caratteristiche e vantaggi

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500977.

Stato fisico

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable