SAB1408617
Anti-PFKFB1 antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
Sinonimo/i:
F6PK, HL2K, MGC116715, MGC116717, PFRX
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100 μG
489,00 €
489,00 €
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Cambia visualizzazione
100 μG
489,00 €
About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
489,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Stato
buffered aqueous solution
PM
antigen ~54.7 kDa
Reattività contro le specie
human
tecniche
immunofluorescence: suitable
western blot: 1 μg/mL
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... PFKFB1(5207)
Categorie correlate
Descrizione generale
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) is encoded by the gene mapped to human chromosome Xp11.21. The encoded protein is one among the four isoenzymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. PFKFB1 is expressed predominantly in liver.
This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. (provided by RefSeq)
Immunogeno
PFKFB1 (NP_002616.1, 1 a.a. ~ 471 a.a) full-length human protein.
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
Sequence
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYISTKLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYLSHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPDYIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRTVYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLKVWTSRMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLHTVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY
Applicazioni
Anti-PFKFB1 antibody produced in rabbit has been used in western blotting.
Azioni biochim/fisiol
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (PFKFB1) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate. It plays a vital role in regulation of both glycolysis and gluconeogenesis. PFKFB1 also facilitates cell growth and apoptosis.
Stato fisico
Solution in phosphate buffered saline, pH 7.4
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
6-Phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 is essential for p53-null cancer cells.
Ros S, et al.
Oncogene, 36(23), 3287-3287 (2017)
A pericentric inversion of chromosome X disrupting F8 and resulting in haemophilia A
Xin Y, et al.
Journal of Clinical Pathology (2017)
Gene expression analysis of epidermolysis bullosa simplex with mottled pigmentation
Bchetnia M, et al.
Journal of Dermatological Science, 69(1), 80-82 (2013)
R S Batra et al.
Genomics, 40(2), 358-361 (1997-03-01)
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) catalyzes the synthesis and degradation of fructose-2,6-bisphosphate, a potent regulator of glycolysis. Previous studies assigned the gene for human liver PFK-2/FBPase-2 (HGMW-approved symbol PFKFB1) to the X chromosome; however, precise localization remained ambiguous, with the gene variously placed
S Ros et al.
Oncogene, 36(23), 3287-3299 (2017-01-17)
The bifunctional enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) controls metabolic flux through allosteric regulation of glycolysis. Here we show that p53 regulates the expression of PFKFB4 and that p53-deficient cancer cells are highly dependent on the function of this enzyme. We found that
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