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Merck
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Documenti

R9157

Sigma-Aldrich

Ro 4-1284

≥98% (HPLC)

Sinonimo/i:

2-Hydroxy-2-ethyl-3-isobutyl-9,10-dimethoxy-1,2,3,4,5,6,7-hexahydrobenzo[a]chinolizine

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About This Item

Formula empirica (notazione di Hill):
C21H33NO3
Numero CAS:
303-75-3
Peso molecolare:
347.49
Numero MDL:
MFCD01663028
Codice UNSPSC:
12352200
ID PubChem:
329824045

Saggio

≥98% (HPLC)

Forma fisica

solid

Solubilità

DMSO: 16 mg/mL

Ideatore

Roche

Temperatura di conservazione

2-8°C

Stringa SMILE

CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C

InChI

1S/C21H33NO3/c1-6-21(23)12-18-17-11-20(25-5)19(24-4)10-15(17)7-8-22(18)13-16(21)9-14(2)3/h10-11,14,16,18,23H,6-9,12-13H2,1-5H3
TUNMGCULOKMBNJ-UHFFFAOYSA-N

Azioni biochim/fisiol

Ro 4-1284 is a reversible VMAT2 inhibitor.

Caratteristiche e vantaggi

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Environment
GHS09

Avvertenze

Warning

Indicazioni di pericolo

H400

Consigli di prudenza

P273

Classi di pericolo

Aquatic Acute 1

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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J E Leysen et al.
European journal of pharmacology, 206(1), 39-45 (1991-01-25)
[3H]Ketanserin was found to label (besides a low amount of 5-HT2 receptors) non-serotonergic binding sites on human platelet membranes. The latter binding was detected in the presence of excess of the 5-HT2 antagonist BW501, and was potently inhibited by tetrabenazine.
A M Dopico et al.
Journal of neurochemistry, 61(2), 481-489 (1993-08-01)
A single dose of x-irradiation was applied on the cephalic end of newborn rats, and the alterations in the noradrenergic afferents to the cerebellum were studied 180 days later. A net increase in the noradrenaline content of cerebellum was found
C R Berry et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 37(12), 2011-2016 (1996-12-01)
Para-[18F]fluorobenzylguanidine ([18F]PFBG) is a newly developed tracer for imaging myocardial sympathetic neuronal innervation. This study investigated the uptake and retention mechanisms of [18F]PFBG in perfused, isolated rat heart. Fluorine-18-PFBG was administered to working rat hearts within the perfusion medium at
E Missirlis et al.
Investigational new drugs, 8(2), 145-147 (1990-05-01)
Inhibition of angiogenesis offers an alternative approach to cancer chemotherapy, since solid tumor growth has an absolute dependency on angiogenesis. We have previously shown that 8,9-dihydroxy-7-methyl-benzo [b]quinolizinium bromide (GPA1734) is a basement membrane synthesis inhibitor, and that this compound acts
Innately hearing impaired Sprague-Dawley rats exhibit audiogenic seizure susceptibility following monoamine depletion.
C E Reigel et al.
Proceedings of the Western Pharmacology Society, 36, 267-271 (1993-01-01)
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