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Q0380

Sigma-Aldrich

Quinone Oxidoreductase 2 (NQO2) human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥100 units/mg protein

Sinonimo/i:

NQO2 human, NRH nitroreductase human, NRH quinone reductase human

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About This Item

Numero MDL:
MFCD03458332
Codice UNSPSC:
12352204
NACRES:
NA.54

Ricombinante

expressed in E. coli

Livello qualitativo

200

Saggio

≥90% (SDS-PAGE)

Forma fisica

lyophilized powder (one vial contains one mg protein)

Attività specifica

≥100 units/mg protein

N° accesso UniProt

P16083

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... NQO2(4835)

Applicazioni

Quinone oxidoreductase 2 has been used in a study to investigate whether recent advances in limiting paraquat′s toxicity makes it safer for use as an herbicide. Quinone oxidoreductase 2 has also been used in a study to investigate the NQO2-mediated toxicity of the chemotherapeutic drug CB1954.
The product from Sigma has been used to identify novel inhibitors of the enzyme NQO2. It has also been used to investigate the effect of afobazole on quinone reductase 2 activity.

Azioni biochim/fisiol

Modulation of NQO2 activity can have effects on the levels and functions of the tumour suppressor, p53. Deletion of NQO2 can alter intra-cellular signalling via the NF-κB pathway.
Unique human oxidoreductase that uses Dihydronicotinamide riboside (NRH) as a cosubstrate, not NAD(P)H. Activates anticancer prodrugs. Putative melatonin receptor.

Definizione di unità

One unit will catalyze the oxidation of one micromole of 1-methyl-1,4-dihydronicotinamide to 1-methylnicotinamide per minute in the presence of menadione at pH 7.4 at 37 °C.

Stato fisico

contains 10% PBS buffer salts

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Effect of Afobazole on Activity of Quinone Reductase 2
Kadnikov IA, et al.
Pharmaceutical Chemistry Journal, 47(10), 514-516 (2014)
Karen A Nolan et al.
Molecular cancer therapeutics, 11(1), 194-203 (2011-11-18)
The National Cancer Institute chemical database has been screened using in silico docking to identify novel nanomolar inhibitors of NRH:quinone oxidoreductase 2 (NQO2). The inhibitors identified from the screen exhibit a diverse range of scaffolds and the structure of one
Paraquat Research. Do Recent Advances In Limiting Its Toxicity Make Its Use Safer?
Baltazar, T., et al.
British Journal of Pharmacology (2012)
K A Nolan et al.
Bioorganic & medicinal chemistry letters, 20(9), 2832-2836 (2010-04-02)
The purpose of the work was to identify novel inhibitors of the enzyme NQO2. Using computational molecular modelling, a QSAR (R(2)=0.88) was established, relating inhibitory potency with calculated binding affinity. From this, the imidazoacridin-6-one, NSC660841, was identified as the most
Faisal Hayat et al.
International journal of molecular sciences, 22(3) (2021-01-28)
As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological outcomes in acute kidney injury (AKI). Pyridones are oxidation products of nicotinamide, its methylated form, and its ribosylated form. While they are
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