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PRS4243

Sigma-Aldrich

Anti-IFN-β antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Interferon, beta 1, fibroblast

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About This Item

Numero MDL:
MFCD00675910
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human, mouse

tecniche

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

N° accesso UniProt

P01574

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... IFNB1(3456)

Descrizione generale

Interferon-β (IFN-β) is a cytokine that belongs to type I interferons. The IFN-β gene is mapped on the human chromosome at 9p21.3.

Immunogeno

a 17 amino acid peptide from near the center of human IFN-b.

Azioni biochim/fisiol

Interferon-β (IFN-β) plays a major role in antibacterial and antiviral defense. It is also involved in apoptosis, cell growth, and autoimmune disorders. It binds to multimeric cell receptors and successful binding results in a cascade of intracellular events.

Linkage

The action of this antibody can be blocked using blocking peptide SBP4243.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Amber Kaplan et al.
Journal of immunology (Baltimore, Md. : 1950), 198(10), 4036-4045 (2017-04-16)
Type I IFNs are a cytokine family essential for antiviral defense. More recently, type I IFNs were shown to be important during bacterial infections. In this article, we show that, in addition to known cytokine functions, IFN-β is antimicrobial. Parts
Dongdong Xu et al.
Bioactive materials, 35, 82-98 (2024-01-29)
Repetitive implant-related infections (IRIs) are devastating complications in orthopedic surgery, threatening implant survival and even the life of the host. Biofilms conceal bacterial-associated antigens (BAAs) and result in a "cold tumor"-like immune silent microenvironment, allowing the persistence of IRIs. To
Stephen Cunningham et al.
Clinical pharmacology and therapeutics, 78(6), 635-646 (2005-12-13)
Interferon IFN-beta is indicated for the treatment of multiple sclerosis. A significant proportion of patients show a poor clinical response to therapy. Type I interferon exerts its effect at least partially through interaction of specific transcription factors with interferon-stimulated response
L Runkel et al.
Pharmaceutical research, 15(4), 641-649 (1998-05-20)
Two recombinant IFN-beta products have been approved for the treatment of multiple sclerosis, a glycosylated form with the predicted natural amino acid sequence (IFN-beta-1a) and a non-glycosylated form that has a Met-1 deletion and a Cys-17 to Ser mutation (IFN-beta-1b).

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