The epitope recognized by PLA0031 maps to a region between residue 2375 and 2425 of human Trithorax 2 using the numbering given in entry NP_055542.1 (GeneID 9757).
Stato fisico
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
Altre note
Human trithorax homolog 2 (TRX2) is a member of the MLL sub-family of proteins that are found in Set1-like histone H3 K4 methyltransferase complexes. TRX2 may function as a transactivator that mediates cell adhesion and cytoskeletal events important to cell growth and survival. TRX2 is also known as MLL2. The MLL2 complex includes MLL2 (TRX2), ASH2, RBQ3, WDR5, hDPY-30, and menin. MLL2 has been shown to interact with ER-alpha to regulate estrogen-induced gene expression and has been implicated in tumorigenesis.
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