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P4663

Sigma-Aldrich

Poly-L-arginine hydrochloride

Poly-L-arginine hydrochloride

mol wt 5,000-15,000

Sinonimo/i:

L-Arginine homopolymer hydrochloride

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10 MG
151,00 €
50 MG
439,00 €
100 MG
787,00 €

151,00 €

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Cambia visualizzazione
10 MG
151,00 €
50 MG
439,00 €
100 MG
787,00 €

About This Item

Numero CAS:
26982-20-7
Numero MDL:
MFCD00166393
Codice UNSPSC:
12352209
eCl@ss:
32160406
ID PubChem:
24898490
NACRES:
NA.26

151,00 €

Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Richiedi un ordine bulk

Stato

powder

PM

5,000-15,000

Colore

white to off-white

applicazioni

cell analysis
detection

Temperatura di conservazione

−20°C

Stringa SMILE

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1
PQEISBBDIRAKGR-LFELFHSZSA-N

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Applicazioni


  • Interfacial Electrostatics of Poly(vinylamine hydrochloride), Poly(diallyldimethylammonium chloride), Poly-L-lysine, and Poly-L-arginine Interacting with Lipid Bilayers.: This research investigates the interactions between poly-L-arginine hydrochloride and lipid bilayers, providing insights into its potential applications in drug delivery systems (McGeachy et al., 2018). (McGeachy et al., 2018).

Qualità

Contains 3% or less ornithine residue.

Risultati analitici

Molecular weight based on viscosity of precursor poly-L-ornithine.

Altre note

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000436295
0000436295
0000423755
0000423753
0000423753

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Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
Ohtake K, Natsume H, Ueda H, et al.
J. Controlled Release, 82, 263-275 (2002)
Ramsha Aamir et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Ischemic stroke is the most common type of stroke and thrombolytic therapy is the only approved treatment. However, current thrombolytic therapy with tissue plasminogen activator (tPA) is often hampered by the increased risk of hemorrhage. Plasmin, a direct fibrinolytic, has
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
Keerthi Nadimidla et al.
Biopolymers, 107(9) (2017-05-01)
Tau protein plays a major role in Alzheimer's disease. The tau protein loses its functionality by self-aggregation due to the two six-amino acid sequences VQIVYK and VQIINK of the protein. Hence it is imperative to find therapeutics that could inhibit
Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 1838-1845 (2003)
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Articoli

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

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Domande

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 risposta

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Utile?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 risposta

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Utile?

Recensioni

Filtri attivi

    • Recensioni 2
    • Voti 2
    1 su 5 stelle.

    Poor quality product

    This product was useless as it could not be sterile filtered without clogging the membrane. We checked it on SDS PAGE and confirmed the presence of very high molecular weight aggregates. We will ask for a refund. This was found with two separate batches, so it was not a bad batch issue.

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    Utile?

    1. Risposta di Sigma-Aldrich Corporation:

      Thank you for taking the time to leave a review! We are sorry to hear that your experience did not meet expectations. We would like to learn more about your experience to see if there is anything we can do to help troubleshoot this issue. When you have a moment, please contact us by visiting https://www.sigmaaldrich.com/support/customer-support and submit a Report Product Issue ticket. We look forward to hearing from you soon!

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