About This Item
Prodotti consigliati
Ricombinante
expressed in E. coli
Livello qualitativo
Forma fisica
solution
Temperatura di conservazione
−20°C
Stringa SMILE
Cl.CN(C)CCOc1ccc2OCCOc2c1
InChI
1S/C12H17NO3.ClH/c1-13(2)5-6-14-10-3-4-11-12(9-10)16-8-7-15-11;/h3-4,9H,5-8H2,1-2H3;1H
VRCSNYKNBODDIM-UHFFFAOYSA-N
Applicazioni
p30 is an endogenous truncated form of p39 that associates with Cdk5 to form Nclk, which regulates neurotransmission, axon guidance, central nervous system (CNS) architecture, and pathogenesis. Therefore, p30 is useful in studying neurodegenerative diseases such as Alzheimer′s, Amyotrophic Lateral Sclerosis, and Parkinson′s Disease.
Azioni biochim/fisiol
P30 activates GST-Neuronal cyclin-dependent kinase 5 (Cdk5). It also associates with Cdk5 to form an activated neuronal Cdc2-like kinase (Nclk). Product P1246 is recombinant, from bovine and is expressed in E. coli.
Definizione di unità
One unit will incorporate 1 picomole of phosphate into histone H1 peptide per minute at pH 7.2 at 30 °C.
Stato fisico
p30 is supplied in a solution of 25 mM Tris, pH 7.4, 1 mM DTT, and 30% glycerol. (0.5 μg protein/ 25 ul vial)
Nota sulla preparazione
Expressed as a GST fusion protein.
Codice della classe di stoccaggio
10 - Combustible liquids
Certificati d'analisi (COA)
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Shirley B Shelton et al.
Journal of neurochemistry, 88(6), 1313-1326 (2004-03-11)
Cyclin-dependent kinase-5 (CDK5) is predominantly active in the nervous system and it is well established that CDK5 is essential in neuronal development. In addition to its recognized role in development, there is increasing evidence that CDK5 may be involved in
Y Honjyo et al.
Neuroreport, 10(16), 3375-3379 (1999-12-22)
We examined the immunohistochemical localization of p39, the regulatory subunit of cyclin-dependent kinase 5 (Cdk5), in the adult rat brain. Cdk5 requires either p39 or p35 to assume its active form in the mammalian CNS. We developed a specific antibody
X H Cai et al.
Neuroscience research, 28(4), 355-360 (1997-08-01)
We previously reported that a neuron-specific Cdk5 activator, p35nck5ai, was most prominent in the newborn rat brain. In the adult brain, the expression decreased in most regions except hippocampus and primary olfactory cortex. A novel neuron-specific Cdk5 activator, p39nck5ai, has
D Tang et al.
The Journal of biological chemistry, 270(45), 26897-26903 (1995-11-10)
Neuronal Cdc2-like kinase is a heterodimer of Cdk5 and a 25-kDa subunit that is derived from a 35-kDa brain- and neuron-specific protein called the neuronal Cdk5 activator (p35/p25nck5a) (Lew, J., Huang, Q.-Q., Qi, Z., Winkfein, R. J., Aebersold, R., Hunt
M Zheng et al.
Journal of neurobiology, 35(2), 141-159 (1998-05-15)
The ubiquitously expressed cyclin-dependent kinase 5 (cdk5) is essential for brain development. Bioactivation of cdk5 in the brain requires the presence of one of two related regulatory subunits, p35 and p39. Since either protein alone can activate cdk5, the significance
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