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P105

Sigma-Aldrich

(±)-PPHT hydrochloride

≥98% (HPLC), solid

Sinonimo/i:

(±)-2-(N-Phenethyl-N-propyl)amino-5-hydroxytetralin hydrochloride, N-0434

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About This Item

Formula empirica (notazione di Hill):
C21H27NO · HCl
Numero CAS:
71787-90-1
Peso molecolare:
345.91
Numero MDL:
MFCD00055157
Codice UNSPSC:
12352200
ID PubChem:
24277925

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

off-white

Solubilità

DMSO: ≥10 mg/mL
H2O: ≥2 mg/mL

Stringa SMILE

Cl[H].CCCN(CCc1ccccc1)C2CCc3c(O)cccc3C2

InChI

1S/C21H27NO.ClH/c1-2-14-22(15-13-17-7-4-3-5-8-17)19-11-12-20-18(16-19)9-6-10-21(20)23;/h3-10,19,23H,2,11-16H2,1H3;1H
XWLCIDLCEZAOEY-UHFFFAOYSA-N

Informazioni sul gene

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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Azioni biochim/fisiol

A series of new dopamine (DA) receptor agonists, of the 2-aminotetralin group, i.e. N-0434, N-0437 and N-0734 were investigated in both in vivo and in vitro pharmacological test systems. In vivo, the reversal of the gamma-butyrolactone-induced increase in rat central DOPA biosynthesis rate was taken as a measure of presynaptic activity. The homovanillic acid (HVA) decrease, after intraperitoneal and after oral administration of the drugs was also taken as a measure of presynaptic activity. Postsynaptic activity was measured in two behavioural models, i.e. reserpine reversal and stereotypy induction. The effects of (±)-PPHT (N-0434) these drugs on noradrenaline and dopamine turnover (alpha-MpT method) were studied in addition. The results indicate that all three compounds N-0434 ((±)-PPHT), N-0437 and N-0734 are potent and selective DA agonists that lack significant alpha 2 activity.
Potent D2 dopamine receptor agonist.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Z Merali et al.
European journal of pharmacology, 191(3), 281-293 (1990-12-04)
Central administration of bombesin elicits excessive grooming and locomotor activity in rats. This grooming activity is one characterised by vigorous scratching of the face, nape and body flanks. Pretreatment with the D1 receptor antagonist SCH 23390 inhibited the expression of
Y Ikarashi et al.
Neurochemistry international, 30(2), 191-197 (1997-02-01)
The effect of dopamine (DA) D2 receptor on extracellular choline (Ch) and acetylcholine (ACh) levels in rat caudate-putamen (striatum) was investigated by means of microdialysis. The systemic, intraperitoneal (i.p.), injection of (+/-)-2-(N-phenylethyl-N-propyl) amino-5-hydroxytetralin (N-434), a specific DA D2 receptor agonist
B Kanyicska et al.
Endocrinology, 138(8), 3141-3153 (1997-08-01)
Endothelin-1 (ET-1) inhibits PRL secretion from cultured rat lactotrophs. However, ET-1 stimulates PRL secretion after cultured lactotrophs have been exposed for 48 h to dopamine or D2 dopamine agonists. In the present study, we have used cell-attached and inside-out patch
M E Meyer et al.
Pharmacology, biochemistry, and behavior, 44(4), 865-868 (1993-04-01)
The effects of a dopamine agonist, (+/-)-2-(N-penylethyl-N-propyl)amino-5- hydroxytetralin (N-0434) (SC doses of 0.00, 0.01, 0.1, and 1.0 mg/kg) were tested in rats for 120 min in an activity monitor. The durations in seconds of horizontal locomotor time, rearing time, stereotypy
G Díaz-Véliz et al.
Pharmacology, biochemistry, and behavior, 62(1), 21-29 (1999-02-11)
The influence of the hormonal condition on the reactivity of central dopamine (DA) receptors was studied in male and in intact and ovariectomized (OVX) female rats. They were injected with selective DA agonists, acting either on D1 (SKF 38393, 2.5
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