O3764

Oxcarbazepine

≥98% (HPLC), solid

• Sinonimo/i: 10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide, Oxacarbazepine
• Formula empirica (notazione di Hill): C₁₅H₁₂N₂O₂
• Numero CAS: 28721-07-5
• Peso molecolare: 252.27
• Numero CE: 249-188-8
• Numero MDL: MFCD00865307
• Codice UNSPSC: 12352200
• ID PubChem: 24724563
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: solid
• Colore: white
• Solubilità: DMSO: ~9 mg/mL
• Ideatore: Novartis
• Stringa SMILE: O=C1CC2=C(C=CC=C2)N(C(N)=O)C3=CC=CC=C31
• InChI: 1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19); CTRLABGOLIVAIY-UHFFFAOYSA-N
• Informazioni sul gene: human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335) ; rat ... Scnn1g(24768)

Descrizione

Descrizione generale

Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia. The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels. OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus.

Applicazioni

Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells.

Azioni biochim/fisiol

Anticonvulsant, antineuralgic. Inhibits veratrine-induced transmitter release.

Caratteristiche e vantaggi

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)