N0513
Nerve Growth Factor-7S from murine submaxillary gland
NGF-7S, lyophilized powder, suitable for cell culture
Sinonimo/i:
NGF-7S
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About This Item
Prodotti consigliati
Origine biologica
mouse
Forma fisica
lyophilized powder
Potenza
2-250 ng/mL ED50/EC50
Qualità
endotoxin tested
PM
protein 130 kDa
Confezionamento
pkg of 0.1 mg
tecniche
cell culture | mammalian: suitable
Impurezze
≤10
Colore
white
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Ngf(18049)
Descrizione generale
Nerve growth factor (NGF) is a dimer of 118-residue polypeptide chains linked non-covalently. Both these polypeptides contain three intramolecular disulphide bridges. It forms the prototype of the neurotrophin growth factor family. In male mouse submandibular salivary gland, NGF is present in high amounts, and is present as a high molecular weight complex called nerve growth factor-7S (NGF-7S). NGF-7S is an α2β2γ2 complex, where β2-NGF is the active neurotrophin, and is linked to the dimers of the glandular kallikrein serine proteinases members, α-NGF and γ-NGF.
Applicazioni
Nerve Growth Factor-7S (NGF-7S) from murine submaxillary gland has been used for the treatment of following cells to induce neuronal differentiation-
- PC12
- Dorsal root ganglia (DRG) obtained from chick embryos of either sex (Gallus gallus)
Azioni biochim/fisiol
Nerve growth factor (NGF) is a neurotrophin, which facilitates the differentiation and survival of specific subtypes of neurons of central nervous system and peripheral nervous system. However, nerve growth factor-7S (NGF-7S) lacks any neurotrophic activity as most part of β-NGF subunit is buried within the NGF-7S complex.
Stato fisico
Lyophilized from 0.2 μm filtered solution in 25 mM sodium phosphate, pH 7.0.
Nota sulla preparazione
Nerve growth factor-7S (NGF-7S) is isolated from male mouse submaxillary glands using a modification of the method of Varon, et al.
Risultati analitici
The biological activity is measured using a 3-day MTT assay.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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