MAK376
Covidyte™ IF670 Substrate
sufficient for 100 fluorometric tests
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Codice UNSPSC:
12352200
Prodotti consigliati
impiego
sufficient for 100 fluorometric tests
applicazioni
pharmaceutical
Metodo di rivelazione
fluorometric
Malattie correlate
immunological diseases; pulmonary disorders
Temperatura di conservazione
−20°C
Descrizione generale
The coronavirus main protease, which plays a pivotal role in viral gene expression and replication through the proteolytic processing of replicase polyproteins, is an attractive target for anti-CoV drug design. The inhibition of viral proteases necessary for proteolytic processing of polyproteins has been a successful strategy in the treatment of human immunodeficiency virus (HIV) and hepatitis C respectively, proving the potential of protease inhibitors for the treatment of viral infections. Similarly, the main protease of SARS-CoV-2 is thought to be essential for viral replication and is therefore regarded as a promising target for antiviral therapy of Covid-19.
Caratteristiche e vantaggi
Compatible with high-throughput handling systems.
Compatibilità
Suitable for developing methods to screen potential inhibitors of coronavirus proteases
Principio
Covidyte IF670 is a peptide substrate containing a 12-amino acid sequence (VNSTLQSGLRKM) that can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide Quencher™ 5 (TQ5) as a quencher and iFluor 670 as a fluorescent donor on the N- and C- terminals respectively where the fluorescence of iFluor 670 is effectively quenched by TQ5 when the peptide is intact. When the peptide is hydrolyzed by coronavirus proteases, the iFluor 670 fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by TQ5. The activity of coronavirus proteases can be effectively monitored by the fluorescence intensity of iFluor 670.
Altre note
For additional information on our range of Biochemicals, please complete this form.
Note legali
Covidyte is a trademark of AAT Bioquest, Inc.
Tide Quencher is a trademark of AAT Bioquest, Inc.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Scegli una delle versioni più recenti:
Certificati d'analisi (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.
Se ti serve aiuto, non esitare a contattarci Servizio Clienti
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Filtri attivi
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.
