This kit is sufficient to perform 100 tests in a 96-well plate format, including standards and duplicates. Please see the link below to review the product data sheet: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/125/489/mak257bul.pdf
MAK257
Tyrosinase Inhibitor Screening Kit (Colorimetric)
sufficient for 100 colorimetric tests
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About This Item
Codice UNSPSC:
12161503
NACRES:
NA.25
Prodotti consigliati
applicazioni
cosmetics
food and beverages
Metodo di rivelazione
colorimetric
Malattie correlate
dermatological diseases
Temperatura di conservazione
−20°C
Descrizione generale
Tyrosinase or polyphenol oxidase (EC 1.14.18.1), is an oxidoreductase that participates in the biosynthesis of melanin, a ubiquitous biological pigment found in hair, eyes, skin, etc. Inhibition of tyrosinase has been a long-time target in the skin health research, cosmetics and agricultural industries because of its role in browning reactions in skin pigmentation and during fruit harvesting and handling. Skin whitening and bleaching products utilize natural or synthetic tyrosinase inhibitors in order to lighten the skin color. Polyphenols, benzaldehyde derivatives, long-chain lipids, steroids, and natural compounds have been used as tyrosinase inhibitors.
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.[1]
Deficiency in tyrosinase causes albino, a condition in which the melanocytes are not able to produce melanin. This increases the risk of skin cancer.[1]
Caratteristiche e vantaggi
Compatible with high-throughput handling systems.
Compatibilità
Suitable for screening/studying/characterizing tyrosinase inhibitors.
Principio
Tyrosinase catalyzes the oxidation of tyrosine, producing a chromophore that can be detected at 510 nm. In the presence of kojic acid, a reversible inhibitor of tyrosinase, the rate of oxidation of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of tyrosinase inhibitors. The assay is also adaptable to a 384 well format.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Dam. 1 - Resp. Sens. 1
Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
188.6 °F
Punto d’infiammabilità (°C)
87 °C
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