M6885
1-Methyluric acid
Sinonimo/i:
1-Methyl-2,6,8-trihydroxypurine, 1-U, 1MUA
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About This Item
Formula empirica (notazione di Hill):
C6H6N4O3
Numero CAS:
Peso molecolare:
182.14
Beilstein:
195190
Numero CE:
Numero MDL:
Codice UNSPSC:
41106305
ID PubChem:
NACRES:
NA.51
Prodotti consigliati
Saggio
≥98% (HPLC)
Stato
powder
Solubilità
1 M NaOH: 20 mg/mL, clear to slightly hazy
Stringa SMILE
CN1C(=O)NC2=C(NC(=O)N2)C1=O
InChI
1S/C6H6N4O3/c1-10-4(11)2-3(9-6(10)13)8-5(12)7-2/h1H3,(H,9,13)(H2,7,8,12)
QFDRTQONISXGJA-UHFFFAOYSA-N
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Applicazioni
1-Methyluric acid has been used:
- for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
- in turbidimetric assay of synthetic urine samples
- as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay
Azioni biochim/fisiol
1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.
Confezionamento
Bottomless glass bottle. Contents are inside inserted fused cone.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Xanthine urolithiasis: Inhibitors of xanthine crystallization
Grases F, et al.
bioRxiv, 335364-335364 (2018)
Theophano A Psarra et al.
Fundamental & clinical pharmacology, 22(5), 537-547 (2008-10-11)
The present study, aimed to clarify whether the gastrointestinal adverse effects following administration of the bronchodilator theophylline are owing to the action of the drug itself or its metabolites, investigates the pharmacodymanic effects of theophylline's metabolites on the spontaneous contractility
C Lee
Clinica chimica acta; international journal of clinical chemistry, 295(1-2), 141-154 (2000-04-18)
Although caffeine has been suggested as an antioxidant at millimolar concentrations, little information is available about the antioxidant activity of caffeine and its metabolites at physiological concentrations. Antioxidant activity was measured by oxygen-radical absorbing capacity (ORAC) using 2, 2'-azobis(2-amidinopropane) dihydrochloride
Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9
DeBosch BJ, et al.
Nature Communications, 5, 4642-4642 (2014)
José Angel Gómez-Ruiz et al.
Journal of agricultural and food chemistry, 55(17), 6962-6969 (2007-07-28)
In this paper we report the antioxidant activity of different compounds which are present in coffee or are produced as a result of the metabolism of this beverage. In vitro methods such as the ABTS*+ [ABTS = 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)] decolorization
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