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M3895

Sigma-Aldrich

Mucin from bovine submaxillary glands

Type I-S

Sinonimo/i:

MUC

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About This Item

Numero CAS:
84195-52-8
Numero CE:
282-357-4
Numero MDL:
MFCD00131629
Codice UNSPSC:
12352202
NACRES:
NA.61

Origine biologica

bovine submaxillary glands

Tipo

Type I-S

Forma fisica

powder

Composizione

Bound sialic acids, 9-24%

tecniche

electrophoresis: suitable

N° accesso UniProt

P98091

Temperatura di conservazione

−20°C

Informazioni sul gene

cow ... BSM(286841)

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Categorie correlate

Descrizione generale

Mucin from bovine submaxillary glands is encoded by two bovine submaxillary BSM genes. It is present in the saliva and interacts with air and food. Mucin comprises three major domains namely N- and C terminal and the glycosylated proline, threonine and serine (PTS domain) central domain. The sialic acid contributes to 30% of the molecular weight of mucin. The central domain has many tandem repeats.

Applicazioni

Mucin from bovine submaxillary glands has been used:
  • in the quantification of mucin
  • as a component of artificial tear solution
  • as a substrate for recombinant sialidase Gardnerella vaginalis
  • to investigate a galactose-specific lectin from the red marine alga Ptilota filicina
  • to study the characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa)

Azioni biochim/fisiol

Bovine submaxillary mucin (BSM) is thermally stable up to 85°C. The terminal domain regions are key for the adsorption functionality of mucin.
Albuminoid substance in mucus which gives it its ropy consistency

Linkage

Similar to M 4503, but produced by Sigma.

Substrati

Neuraminidase substrate.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sasi B Yarragudi et al.
Carbohydrate polymers, 163, 216-226 (2017-03-08)
Targeted delivery and retention of drug formulations in the olfactory mucosa, the target site for nose-to-brain drug absorption is a major challenge due to the geometrical complexity of the nose and nasal clearance. Recent modelling data indicates that 10μm-sized microparticles
Late therapeutic intervention with a respiratory syncytial virus L-protein polymerase inhibitor, PC786, on respiratory syncytial virus infection in human airway epithelium
Brookes DM, et al.
British Journal of Pharmacology, 175(12), 2520-2534 (2018)
A H Sampaio et al.
Phytochemistry, 48(5), 765-769 (1998-07-17)
A lectin from the red marine alga Ptilota filicina (PFL) was isolated by affinity chromatography on cross-linked guar gum. PFL agglutinated native and papain-treated human erythrocytes with preference for type O erythrocytes. The lectin was inhibited by galactose and its
The central domain of bovine submaxillary mucin consists of over 50 tandem repeats of 329 amino acids: Chromosomal localization of the BSM1 gene and relations to ovine and porcine counterparts
Jiang W, et al.
European Journal of Biochemistry, 267(8), 2208-2217 (2000)
Proteolytic degradation of bovine submaxillary mucin (BSM) and its impact on adsorption and lubrication at a hydrophobic surface
Madsen JB, et al.
Langmuir, 31(30), 8303-8309 (2015)
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Articoli

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