K4019

KHS101

≥98% (HPLC)

• Sinonimo/i: N4-isobutyl-N2-((2-phenylthiazol-4-yl)methyl)pyrimidine-2,4-diamine
• Formula empirica (notazione di Hill): C₁₈H₂₁N₅S
• Numero CAS: 1262770-73-9
• Peso molecolare: 339.46
• Numero MDL: MFCD18206916
• Codice UNSPSC: 12352200
• ID PubChem: 329817142
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: off-white to light brown
• Solubilità: DMSO: ≥20 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1
• InChI: 1S/C18H21N5S/c1-13(2)10-20-16-8-9-19-18(23-16)21-11-15-12-24-17(22-15)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3,(H2,19,20,21,23); DGRJOOOHPBSAHD-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

KHS101 is a small molecule differentiator of neuronal differentiation: TACC3 binder.

KHS101 is a small molecule that drives neuronal differentiation of hippocampal neuronal progenitor cells (NPC). Treatment of NPCs with KHS101 induces expression of the neurogenic transcription factor NeuroD and the neuronal marker Tuj1, and exhibit neuronal morphology and spiking activity (EC50 1 uM). KHS101 binds tightly to TACC3, which is a structural component of the centrosome and mitotic spindle apparatus. TACC3 loss of function studies in mice and stem cells suggest that TACC3 controls progenitor cell expansion and terminal differentiation during development.

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H413
• Consigli di prudenza: P273 - P301 + P310 + P330
• Classi di pericolo: Acute Tox. 3 Oral - Aquatic Chronic 4
• Codice della classe di stoccaggio: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable