I2273

3-Indoleacrylic acid

BioReagent, ≥98% (HPLC)

• Sinonimo/i: 3-(3-Indolyl)acrylic acid, IAA
• Formula empirica (notazione di Hill): C₁₁H₉NO₂
• Numero CAS: 1204-06-4
• Peso molecolare: 187.19
• Beilstein: 6317
• Numero CE: 214-872-7
• Numero MDL: MFCD00005633
• Codice UNSPSC: 12352106
• ID PubChem: 24895972
• NACRES: NA.52

Proprietà

• Grado: Molecular Biology; for molecular biology
• Nome Commerciale: BioReagent
• Saggio: ≥98% (HPLC)
• Stato: powder
• PM: 187.19 g/mol
• Temperatura di conservazione: room temp
• Stringa SMILE: OC(=O)\C=C\c1c[nH]c2ccccc12
• InChI: 1S/C11H9NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-7,12H,(H,13,14)/b6-5+; PLVPPLCLBIEYEA-AATRIKPKSA-N

Descrizione

Descrizione generale

3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. This expression system requires that the gene of interest is cloned in plasmids containing the trpE promoter.

Applicazioni

3-Indoleacrylic acid has been used in the induction of ribokinase expression in E. coli.[1]

Azioni biochim/fisiol

3-Indoleacrylic acid (IAA) is metabolized from tryptophan and this conversion is carried out by gut microflora.[2] 3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription.[3] The IAA induced expression system requires the gene of interest cloned in plasmids containing the trp promoter.[3] It promotes the barrier functionality of the intestinal epithelial cells. IAA also favors anti-inflammatory response and is regarded as a potential therapeutic to treat inflammatory bowel disease (IBD).[4] It is also implicated in a variety of cellular processes including apoptosis, autophagy, cell proliferation and migration. In tumor cells, IAA is also reported to hinder tryptophan metabolism. [5]

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves