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Documenti fondamentali

GW21071

Sigma-Aldrich

Anti-PI3K antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β isoform

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

rat, mouse, human

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... PIK3CB(5291)

Immunogeno

Immunogen Sequence: GI # 5453894, sequence 58-134
Recombinant phosphoinositide-3-kinase, catalytic, β polypeptide

Applicazioni

Anti-PI3K antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit β isoform is an enzyme encoded by the PIK3CB gene in humans. It has been implicated as a participant in signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. PI 3-kinase exhibits different isoforms and has a define family of genes encoding distinct PI 3-kinase catalytic subunits that can associate with p85. It is commonly activated in tumors. PI3K pathway is activated in tumors and most commonly through p110α mutation or PTEN deletion.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Hashem A Dbouk et al.
PloS one, 8(5), e63833-e63833 (2013-06-05)
The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic
Lan Liu et al.
Oncology letters, 14(3), 3741-3747 (2017-09-21)
Catalpol is an effective active ingredient that functions as a diuretic and laxative, and exhibits blood sugar-lowering, liver protective, anti-aging and anticancer effects. In traditional Chinese medicine, catalpol is believed to be Yin nourishing. The anticancer effect of catalpol on
Hashem A Dbouk et al.
Oncotarget, 1(8), 729-733 (2011-02-16)
The PI3K pathway is frequently activated in tumors, most commonly through p110α mutation or PTEN deletion. In contrast to p110α, p110β is oncogenic when over-expressed in the wild-type state, suggesting that its regulation by p85 is different than that of
Dongjin Lv et al.
Molecular medicine reports, 23(3) (2021-01-27)
Long non‑coding RNAs (lncRNAs) are involved in the occurrence and progression of numerous types of cancer. The aim of the present study was to evaluate the effect of the lncRNA maternally expressed gene 3 (MEG3) on the migration and invasion of
P Hu et al.
Molecular and cellular biology, 13(12), 7677-7688 (1993-12-01)
Phosphatidylinositol 3-kinase (PI 3-kinase) has been implicated as a participant in signaling pathways regulating cell growth by virtue of its activation in response to various mitogenic stimuli. Here we describe the cloning of a novel and ubiquitously expressed human PI

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