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G8671

Sigma-Aldrich

PDGFRβ(557-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinonimo/i:

CD140B, JTK12, PDGFR1

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10 μG
371,00 €

371,00 €

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Cambia visualizzazione
10 μG
371,00 €

About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

371,00 €

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Ricombinante

expressed in baculovirus infected Sf9 cells

Livello qualitativo

200

Nome Commerciale

PRECISIO® Kinase

Saggio

≥70% (SDS-PAGE)

Stato

buffered aqueous glycerol solution

Attività specifica

16-22 nmol/min·mg

PM

~104 kDa

N° accesso UniProt

P09619

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... PDGFRB(5159)

Descrizione generale

PDGFRB (platelet derived growth factor receptor β) is a type III tyrosine kinase receptor, which exists as a homodimer. This receptor interacts with multiple ligands, but its main physiological ligand is PDGF-BB homodimer.[1]

Azioni biochim/fisiol

PDGFRB (platelet derived growth factor receptor β), upon interaction with PGDFB, regulates multiple processes such as, sclerotic disorders, wound healing and tumor angiogenesis. Gain-of-function mutation in this gene is linked with Penttinen syndrome, which is an autosomal-dominant disorder.[1] Release of PGDFB by endothelial cells results in the activation of this receptor, which is essential for the recruitment of PDGFRB+ vascular smooth muscle cells and pericytes during blood vessel formation. Loss-of-function mutation in this gene results in the neurodegenerative disorder primary familial brain calcification (PFBC).[2]

Stato fisico

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Note legali

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number

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Lei Xu et al.
Cancer research, 65(13), 5711-5719 (2005-07-05)
Renal cell carcinoma is a highly malignant and often fatal disease of the kidney. It is difficult to treat, often because metastases are common at the time of presentation. Platelet-derived growth factor-D (PDGF-D) is a newly discovered member of the
P Soriano
Genes & development, 8(16), 1888-1896 (1994-08-15)
Platelet-derived growth factor, a major mitogen and chemoattractant for a number of cell types, is implicated in the processes of wound healing, tumorigenesis, and differentiation and is recognized by two receptors, alpha and beta. To begin understanding the role of
Michael Vanlandewijck et al.
PloS one, 10(11), e0143407-e0143407 (2015-11-26)
Primary Familial Brain Calcification (PFBC), a neurodegenerative disease characterized by progressive pericapillary calcifications, has recently been linked to heterozygous mutations in PDGFB and PDGFRB genes. Here, we functionally analyzed several of these mutations in vitro. All six analyzed PDGFB mutations
Jennifer J Johnston et al.
American journal of human genetics, 97(3), 465-474 (2015-08-19)
Penttinen syndrome is a distinctive disorder characterized by a prematurely aged appearance with lipoatrophy, epidermal and dermal atrophy along with hypertrophic lesions that resemble scars, thin hair, proptosis, underdeveloped cheekbones, and marked acro-osteolysis. All individuals have been simplex cases. Exome

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