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F8507

Sigma-Aldrich

(±)-Fenfluramine hydrochloride

Sinonimo/i:

(±)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C12H16F3N · HCl
Numero CAS:
16105-77-4
Peso molecolare:
267.72
Numero MDL:
MFCD00058016
Codice UNSPSC:
12352200
ID PubChem:
24894965

Controllo stupefacenti

USDEA Schedule IV

applicazioni

forensics and toxicology

Stringa SMILE

Cl.CCNC(C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H
ZXKXJHAOUFHNAS-UHFFFAOYSA-N

Informazioni sul gene

human ... HTR1D(3352) , HTR2C(3358) , SIGMAR1(10280)

Azioni biochim/fisiol

Neurotoxic on prolonged administration or at high dosage; releases serotonin from axon terminals by a nonexocytotic mechanism; anorectic

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Consigli di prudenza

P301 + P310

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
093K1065
024K1165
112K0643
077F0787
052K1359

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Justin N Siemian et al.
British journal of pharmacology, 175(9), 1519-1534 (2018-02-17)
Although the antinociceptive efficacies of imidazoline I2 receptor agonists have been established, the exact post-receptor mechanisms remain unknown. This study tested the hypothesis that monoaminergic transmission is critical for I2 receptor agonist-induced antinociception. von Frey filaments were used to assess
J D Roth et al.
European journal of pharmacology, 373(2-3), 127-134 (1999-07-22)
Fenfluramine + phentermine was a widely used combination for weight loss. Fenfluramine and phentermine are believed to act via serotonin and catecholamines, respectively. To what extent these drugs interact has not been well-established. We compared the anorectic efficacy of a
Y X Wang et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1008-1016 (1999-11-24)
Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The current study compared the antinociceptive properties of fenfluramine with those of the tricyclic antidepressants amitriptyline and desipramine
Eileen K Sawyer et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(8), 1816-1824 (2012-03-22)
Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration. In
Shoko Sato et al.
Biological & pharmaceutical bulletin, 35(10), 1697-1702 (2012-08-02)
We investigated whether postweaning protein malnutrition (PM) affects serotonergic systems. Mice were fed a PM diet or normal protein (control) diet from weaning (21 d of age). Twenty days later, we tested for behavioral effects of the selective serotonin (5-HT)(1A)
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