E7906

Esomeprazole

≥98% (HPLC), proton pump inhibitor, powder

• Sinonimo/i: (T-4)-Bis[5-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazolato]magnesium, Nexium, Omeprazole
• Formula empirica (notazione di Hill): C₃₄H₃₆MgN₆O₆S₂ · xH₂O
• Numero CAS: 668985-31-7
• Peso molecolare: 713.12 (anhydrous basis)
• MDL number: MFCD11226784
• UNSPSC Code: 12352200
• PubChem Substance ID: 329799074
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Nome del prodotto: Esomeprazole, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D -128 to -146°, c = 0.5 in methanol
• color: white to off-white
• solubility: DMSO: ≥5 mg/mL
• originator: AstraZeneca
• storage temp.: 2-8°C
• SMILES string: O.COc1ccc2n([Mg]n3c(nc4cc(OC)ccc34)S(=O)Cc5ncc(C)c(OC)c5C)c(nc2c1)S(=O)Cc6ncc(C)c(OC)c6C
• InChI: 1S/2C17H18N3O3S.Mg.H2O/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;;/h2*5-8H,9H2,1-4H3;;1H2/q2*-1;+2;/t2*24-;;/m00../s1
• InChI key: LGRFYKXKCZKDLS-DIYDTZFBSA-N

Descrizione

General description

Esomeprazole is the (S)-isomer of omeprazole. It blocks the H⁺/K⁺-ATPase enzyme and lowers the release of hydrochloric acid by gastric parietal cells. Esomeprazole is used for treating gastroesophageal reflux disease (GERD).

Application

Esomeprazole magnesium hydrate has been used to induce intracellular acidification in an ATP12A-independent manner.

Biochem/physiol Actions

Esomeprazole magnesium dihydrate is a leading proton pump inhibitor.

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)