Unfortunately, no data for Product D4008's use with flow cytometry application is determined. However, several academic publications associated with this product's use in flow cytometry experiments may provide details that can assist with the experimental design. Please see the link to those publications below:
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C26&q=%22Dansylcadaverine%22+%22D4008%22+%22flow+cytometry%22&btnG=
D4008
Dansylcadaverine
≥97% (TLC)
Sinonimo/i:
N-(5-Aminopentyl)-5-dimethylaminonaphthalene-1-sulfonamide, N-(Dimethylaminonaphthalenesulfonyl)-1,5-pentanediamine, Monodansyl cadaverine
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Cambia visualizzazione
| Voi/SKU | Disponibilità | Prezzo |
|---|---|---|
250 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 76,50 € |
100 mg | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 102,00 € |
1 g | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 616,00 € |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C17H25N3O2S
Numero CAS:
Peso molecolare:
335.46
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
EC Number:
233-326-9
Beilstein/REAXYS Number:
2951070
MDL number:
76,50 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiQuality Segment
assay
≥97% (TLC)
form
powder
technique(s)
protein detection: suitable
storage temp.
−20°C
SMILES string
CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCN
InChI
1S/C17H25N3O2S/c1-20(2)16-10-6-9-15-14(16)8-7-11-17(15)23(21,22)19-13-5-3-4-12-18/h6-11,19H,3-5,12-13,18H2,1-2H3
InChI key
MLEBFEHOJICQQS-UHFFFAOYSA-N
General description
Dansylcadaverine, also called as monodansylcadaverine (MDC), is a lysosomotropic agent. It is present in acidic and lipid rich regions. Dansylcadaverine also acts as a solvent polarity probe. It inhibits vesicular transport and decreases the rotavirus sequestering in L cells, when pre-treated.
Application
Dansylcadaverine in methanol has a reported λex of 335 nm and λem of 512 nm. It has been used:
- as an endocytosis inhibitor in human proximal tubular HK-2 cells,(62) mouse J774A.1 macrophages and human A549 epithelial cells(63)
- to label autophagic vacuoles in cardiomyocytes for fluorescence microscopy studies(64)
- in monodansylcadaverine (MDC) staining of fibroblasts in Ankylosing spondylitis (AS) samples(65)
Biochem/physiol Actions
The autofluorescent dye dansylcadaverine, or monodansylcadaverine (MDC), is commonly used to monitor autophagy. MDC preferentially accumulates in autophagic vacuoles due to a combination of ion trapping and specific interactions with membrane lipids.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
air sensitive, handled under inert gas
Other Notes
Solubility of dansylcadaverine is tested in methanol (10 mg/mL). It has also been reported that dansylcadaverine is soluble in DMSO and acetic acid.
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Questo articolo | |||
|---|---|---|---|
| description ≥97% (TLC) | description BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | description ≥99.0% (AT) | description analytical standard |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. - |
| form powder | form - | form powder | form - |
| assay ≥97% (TLC) | assay ≥99.0% (HPLC) | assay ≥99.0% (AT) | assay 96.5-103.5% (T), ≥96.5% (GC) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
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Parola di avvertenza
Warning
Codici di pericolo
Avvertenze di sicurezza
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Organi bersaglio
Respiratory system
Classe di stoccaggio
11 - Combustible Solids
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
DPI (dispositivi di protezione individuale)
dust mask type N95 (US), Eyeshields, Gloves
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Can I use Dansylcadaverine D4008 for detection of autophagy using flow cytometry? if Yes which laser should we use to detect the MDC signal? Di you have any recommendations regarding the final concentration of MDC for detection of autophagy in lymphocyte?
1 risposta-
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What is the Department of Transportation shipping information for this product?
1 risposta-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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Can Dansylcadaverine be use as a marker of autophagic vacuoles?
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Dansylcadaverine is a lysosomotropic compound that can be used for the identification of autophagic vacuoles. Please refer to the literature for application-specific protocols.
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What is Product D4008, Dansylcadaverine, soluble in?
1 risposta-
We test the solubility of this product in acetic acid at a concentration of 50 mg/mL, with the application of heat and sonication. It has also been reported as being soluble in methanol and DMSO. We have not validated this claim in our labs.
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What is the solution stability of Product D4008, Dansylcadaverine?
1 risposta-
According to one source a stock solution of monodansylcadaverine was prepared in methanol at 50 mM and stored frozen at -20°C. No time frame for long-term solution stability was given.
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