C7971

Cilostamide

phosphodiesterase inhibitor

• Sinonimo/i: 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Formula empirica (notazione di Hill): C₂₀H₂₆N₂O₃
• Numero CAS: 68550-75-4
• Peso molecolare: 342.43
• Numero MDL: MFCD00673958
• Codice UNSPSC: 12352202
• ID PubChem: 24278337
• NACRES: NA.77

Proprietà

• Saggio: ≥97% (HPLC)
• Stato: powder
• Solubilità: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• Stringa SMILE: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23); UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Informazioni sul gene: human ... PDE3A(5139) , PDE3B(5140) , PDE5A(8654) , PDE7A(5150) ; rat ... Pde2a(81743) , Pde4a(25638)

Descrizione

Azioni biochim/fisiol

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures.[1] Cilostamide is known to delay meiotic progression.[2]

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)