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C6509

Sigma-Aldrich

Cholesteryl behenate

≥90% (HPLC; detection at 205 nm)

Sinonimo/i:

3β-Hydroxy-5-cholestene 3-docosanoate, 5-Cholesten-3β-ol 3-docosanoate, Cholesteryl docosanoate

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About This Item

Formula empirica (notazione di Hill):
C49H88O2
Numero CAS:
61510-09-6
Peso molecolare:
709.22
Numero MDL:
MFCD00056440
Codice UNSPSC:
12352200
ID PubChem:
24892872

Saggio

≥90% (HPLC; detection at 205 nm)

Stato

solid

Gruppo funzionale

ester

Condizioni di spedizione

ambient

Temperatura di conservazione

room temp

Stringa SMILE

[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)CCCCCCCCCCCCCCCCCCCCC)[C@H](C)CCCC(C)C

InChI

1S/C49H88O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-29-47(50)51-42-34-36-48(5)41(38-42)30-31-43-45-33-32-44(40(4)28-26-27-39(2)3)49(45,6)37-35-46(43)48/h30,39-40,42-46H,7-29,31-38H2,1-6H3/t40-,42+,43+,44-,45+,46+,48+,49-/m1/s1
WBOQXYUYHINMOC-FTAWAYKBSA-N

Applicazioni

Cholesteryl behenate was used as standard in electrospray ionization tandem mass spectrometry for the analysis of cholesterol and cholesteryl esters.[1]

Azioni biochim/fisiol

Cholesteryl behenate is a cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters.[2] The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.[3]

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
016H1562
066K1536
107H0182
028H0433
120K1582

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G S Ginsburg et al.
Progress in lipid research, 23(3), 135-167 (1984-01-01)
Cholesteryl esters, the intracellular storage form and intravascular transport form of cholesterol, can exist in crystal, liquid crystal and liquid states. The physical state of cholesteryl esters at physiologic temperatures may be a determinant of their pathogenicity. This review has
G S Ginsburg et al.
Biochimica et biophysica acta, 664(1), 98-107 (1981-04-23)
By polarizing microscopy and differential scanning calorimetry we observed that the relative stability of the smectic and cholesteric mesophases of cholesteryl esters of acyl chain length of 20 carbons or more depends on the length of the acyl chain and
Gerhard Liebisch et al.
Biochimica et biophysica acta, 1761(1), 121-128 (2006-02-07)
Analysis of free cholesterol (FC) is not well suited for electrospray ionization (ESI); however, cholesteryl ester (CE) form ammonium adducts in positive ion mode and generate a fragment ion of m/z 369 upon collision-induced fragmentation. In order to allow parallel
W Guo et al.
Biochemistry, 32(35), 9038-9052 (1993-09-07)
Cholesteryl esters are a major lipid constituent of plasma lipoproteins and atherosclerotic lesions. Crystalline and liquid crystalline phases of several cholesteryl esters [oleate (C18:1, omega-9), erucate (C22:1, omega-9), hexanoate (C6:0), decanoate (C10:0), undecanoate (C11:0), myristate (C14:0), palmitate (C16:0), and stearate
Shobha Ghosh et al.
Vascular pharmacology, 52(1-2), 1-10 (2009-11-03)
Accumulation of cholesteryl esters (CE) stored as cytoplasmic lipid droplets is the main characteristic of macrophage foam cells that are central to the development of atherosclerotic plaques. Since only unesterified or free cholesterol (FC) can be effluxed from the cells
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