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C1240

Sigma-Aldrich

Chlormethiazole hydrochloride

≥98% (HPLC), powder

Sinonimo/i:

4-methyl-5-(β-chloroethyl)thiazole hydrochloride, 5-(2-Chloroethyl)-4-methylthiazole hydrochloride, Clomethiazole hydrochloride, Somnevrin hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C6H8ClNS · HCl
Numero CAS:
6001-74-7
Peso molecolare:
198.11
Numero MDL:
MFCD00673948
Codice UNSPSC:
12352200
ID PubChem:
329774745
NACRES:
NA.77

Descrizione

Store desiccated

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

off-white

Solubilità

H2O: soluble >10 mg/mL

Ideatore

AstraZeneca

Stringa SMILE

Cl.Cc1ncsc1CCCl

InChI

1S/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
OFXYKSLKNMTBHK-UHFFFAOYSA-N

Azioni biochim/fisiol

Chlormethiazole serves as an anticonvulsant. It is useful in treating alcohol addiction and eclampsia. Chlormethiazole is also useful in treating convulsive status epilepticus. Long term administration of chlormethiazole leads to addiction to the drug.
GABAA agonist; glycine receptor modulator.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

CorrosionExclamation mark
GHS05,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H317,H318

Classi di pericolo

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Pediatric Critical Care Medicine: Basic Science And Clinical Evidence, 985-985 (2007)
Koichi Nisijima et al.
Neurochemistry international, 43(2), 155-164 (2003-03-07)
The serotonin (5-HT) syndrome is the most serious toxic interaction of antidepressants, but no pharmacotherapy has yet been established. In the present study, we created an animal model of the 5-HT syndrome by intraperitoneally injecting rats with clorgyline (2 mg/kg)
A Nurse's Survival Guide to Acute Medical Emergencies (2011)
M Gasior et al.
The Journal of pharmacology and experimental therapeutics, 295(1), 153-161 (2000-09-19)
Chlormethiazole positively modulates the gamma-aminobutyric acid (GABA)(A) receptor complex and is primarily used to treat certain life-threatening neurological events (e.g., refractory seizures and ethanol withdrawal syndrome). On account of several experimental and clinical studies reporting effectiveness against the toxic effects
Rachael M Nelson et al.
European journal of pharmacology, 452(3), 255-262 (2002-10-03)
Clomethiazole is a gamma-aminobutyric acid (GABA)-mimetic agent with anticonvulsant, sedative and neuroprotective properties. The pharmacological actions of clomethiazole that underlie its functional profile have not been fully explored, but are known to result from an interaction with the GABA(A) receptor.
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