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Key Documents

A8754

Sigma-Aldrich

Methyl α-aminoisobutyrate hydrochloride

Sinonimo/i:

α-Aminoisobutyric acid methyl ester hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C5H11NO2 · HCl
Numero CAS:
Peso molecolare:
153.61
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:

Saggio

≥98% (TLC)

Forma fisica

powder

tecniche

ligand binding assay: suitable

Colore

white

Temperatura di conservazione

−20°C

Stringa SMILE

Cl.COC(=O)C(C)(C)N

InChI

1S/C5H11NO2.ClH/c1-5(2,6)4(7)8-3;/h6H2,1-3H3;1H
NVWZNEDLYYLQJC-UHFFFAOYSA-N

Azioni biochim/fisiol

Methyl α-aminoisobutyrate is used as a specific substrate of amino acid transport system A in studies on amino acid transport systems.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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J W Tsang et al.
Journal of medicinal chemistry, 27(12), 1663-1668 (1984-12-01)
Stereochemical and structural aspects of the variations in the C-terminal residue of L-aspartyl-L-phenylalanine methyl ester have been investigated. Novel configurational analogues such as L-aspartyl-D-alanine benzyl ester and L-aspartyl-D-alpha-aminobutyric acid benzyl ester were found to be sweet. In addition, chiral and
Oak Z Chi et al.
Neurochemical research, 34(7), 1249-1254 (2009-01-08)
This study was performed to determine whether exogenous N-methyl-D: -aspartate (NMDA) or alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) would aggravate blood-brain barrier (BBB) disruption in focal cerebral ischemia in rats. Forty-five minutes after middle cerebral artery (MCA) occlusion, one of the following
A Gadea et al.
Glia, 26(4), 273-279 (1999-06-26)
Rapid termination of the synaptic action of glutamate (Glu) and glycine (Gly) is achieved by uptake into the presynaptic terminal and glial cells. In the vertebrate CNS, Gly acts both as an inhibitory neurotransmitter and as a Glu modulator or
Koichi Kato et al.
Bioorganic & medicinal chemistry letters, 21(8), 2437-2440 (2011-03-12)
We describe the synthesis of (11)C-labeled α-aminoisobutyric acid 2 from iodo[(11)C]methane and methyl N-(diphenylmethylen)-d,l-alaniate (5). The tetrabutylammonium fluoride (TBAF)-promoted α-[(11)C]methylation of sterically hindered analog 5 was a key step in our synthesis process. Total radiochemical conversion of 2 was high

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