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Merck
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A7015

Sigma-Aldrich

N-(2-Fluorenyl)acetamide

≥98% (HPLC)

Sinonimo/i:

2-AAF, 2-Acetamidofluorene, N-Acetyl-2-aminofluorene

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About This Item

Formula empirica (notazione di Hill):
C15H13NO
Numero CAS:
53-96-3
Peso molecolare:
223.27
Beilstein:
2807677
Numero CE:
200-188-6
Numero MDL:
MFCD00001116
Codice UNSPSC:
12352103
ID PubChem:
24891166
NACRES:
NA.25

Saggio

≥98% (HPLC)

Forma fisica

powder

Punto di fusione

192-196 °C (lit.)

Stringa SMILE

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)
CZIHNRWJTSTCEX-UHFFFAOYSA-N

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Applicazioni

N-(2-Fluorenyl)acetamide (2-Acetamidofluorene, 2-AAF), a genotoxic carcinogen, is used to induce liver cancer in animal models such as the 2-AAF/partial hepatectomy rat. 2-AAF may be used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.

Azioni biochim/fisiol

A genotoxic carcinogen that is used to model liver carcinogenesis in rat. When N-hydroxylated by cytochrome CYP1A2 in the liver, 2-AAF forms adducts with DNA and is tumorigenic in liver and bladder.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H350

Classi di pericolo

Acute Tox. 4 Oral - Carc. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Articoli

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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