A5883
8-Azaadenine
≥99%
Sinonimo/i:
6-Amino-8-azapurine, 8-Aza-6-aminopurine
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About This Item
Formula empirica (notazione di Hill):
C4H4N6
Numero CAS:
Peso molecolare:
136.11
Beilstein:
141551
Numero CE:
Numero MDL:
Codice UNSPSC:
12352202
ID PubChem:
Prodotti consigliati
Saggio
≥99%
Stato
powder
Punto di fusione
>300 °C (lit.)
Solubilità
1 M NaOH: 50 mg/mL, clear, colorless to faintly yellow
Temperatura di conservazione
2-8°C
Stringa SMILE
Nc1ncnc2nn[nH]c12
InChI
1S/C4H4N6/c5-3-2-4(7-1-6-3)9-10-8-2/h1H,(H3,5,6,7,8,9,10)
HRYKDUPGBWLLHO-UHFFFAOYSA-N
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Descrizione generale
Base pairs of azaadenine with thymine (and azaguanine with cytosine) are found by ab initio calculation to be up to 7 kcal/mol more stable than natural AT (and GC) base pairs.
Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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A Sahota et al.
Mutation research, 180(1), 81-87 (1987-09-01)
Spontaneous and ethyl methanesulfate induced mutants of Saccharomyces cerevisiae, with partial and complete deficiency of adenine phosphoribosyltransferase (APRT, EC 2.4.2.7), were isolated by selection for resistance to 8-azaadenine. Matings between totally deficient mutants and tester strain resulted in diploid heterozygotes
G Biagi et al.
Farmaco (Societa chimica italiana : 1989), 50(1), 13-19 (1995-01-01)
Comparison of the affinity towards adenosine receptors of 2-phenyl-8-azaadenosines, bearing a lipophilic substituent on N(6), with the corresponding 2-phenyl-8-azaadenines was carried out. The compounds have good A1 affinity and high A1 selectivity. The obtained Ki(rib)/Ki(benz) ratios for A1 receptors, which
Giuliana Biagi et al.
Farmaco (Societa chimica italiana : 1989), 57(3), 221-233 (2002-05-07)
erythro-2-Phenyl-9-(2-hydroxy-3-nonyl)adenine and its 8-aza analog were prepared and showed a very high inhibitory activity towards adenosine deaminase (ADA), with Ki 0.55 and 1.67 nM, respectively, and high affinity for A1 adenosine receptors, with Ki 28 and 2.8 nM, respectively. To
D J Chen et al.
Environmental mutagenesis, 4(4), 457-467 (1982-01-01)
A chinese hamster ovary (CHO) cell line heterozygous at the adenine phosphoribosyl transferase (APRT) locus was used for selection of induced mutants resistant to 8-azaadenine (8AA), 6-thioguanine (6TG), ouabain (OUA), emetine (EMT) and diphtheria toxin (DIP). The expression times necessary
M I Nieto et al.
Nucleosides & nucleotides, 17(7), 1255-1266 (1998-08-26)
Six new carbocyclic nucleosides were prepared by mounting a purine (compounds 5-7), 8-azapurine (compounds 9 and 10) or pyrimidine (compound 13) base on the amino group of (1R,cis)-3-(aminomethyl)-1,2,2-trimethylcyclopentylmethanol (2). The antiviral activity of compounds 5-7, 10 and 13, and their
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