A4559

Amyloid β-Protein Fragment 25-35

≥97% (HPLC)

• Formula empirica (notazione di Hill): C₄₅H₈₁N₁₃O₁₄S
• Numero CAS: 131602-53-4
• Peso molecolare: 1060.27
• Numero MDL: MFCD00133076
• Codice UNSPSC: 12352202
• ID PubChem: 24890880
• NACRES: NA.32

Proprietà

• Livello qualitativo: 200
• Saggio: ≥97% (HPLC)
• Stato: powder
• Composizione: Protein Content, ≥80%
• N° accesso UniProt: P05067
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCC(C)C(NC(=O)C(NC(=O)C(C)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(CO)NC(=O)CN)C(C)CC)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CCSC)C(O)=O
• InChI: 1S/C45H81N13O14S/c1-9-24(5)36(43(69)50-21-35(63)52-29(17-23(3)4)40(66)55-28(45(71)72)14-16-73-8)58-44(70)37(25(6)10-2)57-38(64)26(7)51-34(62)20-49-39(65)27(13-11-12-15-46)54-41(67)30(18-32(48)60)56-42(68)31(22-59)53-33(61)19-47/h23-31,36-37,59H,9-22,46-47H2,1-8H3,(H2,48,60)(H,49,65)(H,50,69)(H,51,62)(H,52,63)(H,53,61)(H,54,67)(H,55,66)(H,56,68)(H,57,64)(H,58,70)(H,71,72); WIHBNMPFWRHGDF-UHFFFAOYSA-N
• Informazioni sul gene: human ... APP(351)

Descrizione

Amino Acid Sequence

Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

Descrizione generale

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is derived from the amyloid-β protein.amyloid-β protein, which is mapped to human chromosome 21q21.[1] Aβ25-35 lacks the N-terminal domain and the metal binding site and is majorly generated by proteolytic cleavage of Aβ(1−40) peptides.[1] It has a β-sheet and β-turn structure.[2]

Applicazioni

Amyloid β-Protein Fragment 25-35 has been used:

• to induce neurotoxicity in cortical cultures[3]
• to induce Alzheimer′s disease in rat model[4]
• to induce apoptosis in mesenchymal stem cells (MSCs)[5]

Azioni biochim/fisiol

Amyloid β-Protein Fragment 25-35 (Aβ25-35) is involved in the pathogenesis of Alzheimer′s disease.[6] Inhibitors of this transition may serve as a potential agent in managing Alzheimer′s disease.[2] It is present in the subiculum and entorhinal cortex neurons of Alzheimer′s brain samples and inclusion-body myositis (IBM) muscle. It binds to receptors present in microglia and is capable of lipid membrane insertion. The functional domain sequence of Aβ comprising of sequence GSNKGAIIGLM elicits neurotrophic and neurotoxic effects. Aβ25-35 exhibits rapid aggregation and displays age dependant neurotoxicity.[7]

Altre note

Lyophilized from 0.1% TFA in H2O

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)