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Merck
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A0851

Sigma-Aldrich

Anti-Angiopoietin-2 antibody produced in goat

affinity isolated antibody, lyophilized powder

Sinonimo/i:

Anti-Ang-2

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About This Item

Numero MDL:
MFCD03096608
Codice UNSPSC:
51111800
NACRES:
NA.41

Origine biologica

goat

Livello qualitativo

100

Ricombinante

expressed in goat

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

PM

antigen ~66 kDa

Reattività contro le specie

human

tecniche

ELISA: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL using human tissue
western blot: 0.1-0.2 μg/mL

N° accesso UniProt

O15123

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ANGPT2(285)

Categorie correlate

Descrizione generale

Angiopoietin 2 is an endothelial cell-specific protein and has a pivotal role in mature blood vessel formation, endothelial cell proliferation and embryogenic angiogenesis. Angiopoietin 2 produced by endothelial cells of interior tumor vessels, stimulates vessel regression and disassociation from surrounding tumor cells. Anti-angiopoietin-2 antibody can be used in western blotting. Goat anti-angiopoietin-2 antibody reacts specifically with recombinant human angiopoietin-2. The product may also show 25% (approx.) cross-reactivity for recombinant human angiopoietin-1.

Immunogeno

purified recombinant human angiopoietin-2 expressed in mouse NSO cells.

Applicazioni

Anti-angiopoietin-2 antibody can be used in immunohistochemistry for detecting humanangiopoietin-2 using paraffin-embedded human tissue sections. It can also be used in ELISA.
Goat anti-angiopoietin-2 antibody is also suitable for use in western blot assays at 0.1-0.2 μg/mL

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (pH 7.4) with 5% trehalose

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Shigetomo Fukuhara et al.
Histology and histopathology, 25(3), 387-396 (2010-01-08)
Angiopoietin (Ang) 1 is a ligand for endothelium-specific receptor tyrosine kinase Tie-2. In adult vasculature, Ang1/Tie2 signaling is thought to regulate both maintenance of vascular quiescence and promotion of angiogenesis. However, it has been unknown how Tie2 signal regulates these
Jawun Choi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 117, 109091-109091 (2019-06-23)
Diosmetin is a natural flavonoid obtained from citrus fruits and some medicinal herbs. Previous studies have reported the anti-cancer activity of diosmetin in some types of tumors. However, it is still unclear whether diosmetin exerts anti-cancer effects, particularly anti-angiogenic effects
Z Zhou et al.
Cell death and differentiation, 22(3), 488-498 (2015-01-13)
Damage and loss of the postmitotic photoreceptors is a leading cause of blindness in many diseases of the eye. Although the mechanisms of photoreceptor death have been extensively studied, few studies have addressed mechanisms that help sustain these non-replicating neurons

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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