435R-1

MCM3 (EP202) Rabbit Monoclonal Primary Antibody

• Codice UNSPSC: 12352202
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: culture supernatant
• Tipo di anticorpo: primary antibodies
• Clone: EP202, monoclonal
• Descrizione: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• Confezionamento: vial of 0.1 mL concentrate (435R-14); vial of 0.5 mL concentrate (435R-15); bottle of 1.0 mL predilute (435R-17); vial of 1.0 mL concentrate (435R-16); bottle of 7.0 mL predilute (435R-18)
• Produttore/marchio commerciale: Cell Marque^®
• tecniche: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• Isotipo: IgG
• Controllo: tonsil
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• Visualizzazione: nuclear
• Informazioni sul gene: human ... MCM3(4172)

Descrizione

Descrizione generale

MCM3, minichromosome maintenance protein 3, belongs to the MCM family of highly conserved group of DNA-binding proteins known to have a role in the initiation and regulation of DNA replication during the cell cycle.^1-7 MCM3 expression is up-regulated in proliferating cells and absent in terminally differentiated cells. Like Ki-67, MCM3 marks proliferating cells. In a study performed by Endl E., et al., Ki-67 and MCM3 double staining was performed on human tonsil showing that MCM3 stains proliferating cells like Ki-67, and in addition marks cells present in the intermediate layer of epithelium (which are typically negative for Ki-67). Both Ki-67 and MCM3 are not detectable in differentiated cells.⁶ However, unlike Ki-67, MCM3 protein down-regulation is delayed. This suggests that Ki-67 may be expressed during a shorter interval of the cell cycle than MCM3. Anti-MCM3 may be a more reliable proliferation marker than anti-Ki-67.¹

Qualità

IVD

IVD

IVD

RUO

Linkage

MCM3 Positive Control Slides, Product No. 435S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Stato fisico

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota sulla preparazione

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Altre note

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Note legali

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