17772

Retinolo

≥95.0% (HPLC), ~2700 U/mg

• Sinonimo/i: tutto trans-3,7-dimetil-9-(2,6,6-trimetil-1-cicloesen-1-il)-2,4,6,8-nonatetraen-1-olo, Alcol della vitamina A, Axeroftolo, Vitamina A, Vitamina A₁
• Formula empirica (notazione di Hill): C₂₀H₃₀O
• Numero CAS: 68-26-8
• Peso molecolare: 286.45
• Beilstein: 403040
• Numero CE: 200-683-7
• Numero MDL: MFCD00001552
• Codice UNSPSC: 12352205
• eCl@ss: 34058018
• ID PubChem: 329751561
• NACRES: NA.79

Proprietà

• Origine biologica: synthetic
• Saggio: ≥95.0% (HPLC)
• Forma fisica: (Powder or Crystal with Lumps)
• Attività specifica: ~2700 U/mg
• Colore: yellow to dark yellow
• Punto di fusione: 61-63 °C (lit.)
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/CO)=C(C)CCC1
• InChI: 1S/C20H30O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,21H,7,10,14-15H2,1-5H3/b9-6+,12-11+,16-8+,17-13+; FPIPGXGPPPQFEQ-OVSJKPMPSA-N

Descrizione

Descrizione generale

Retinal, retinol and retinoic acid are the aldehyde, alcohol and acid forms of vitamin A. The retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinol is biologically active in a wide range of processes.

Retinol or all-trans-retinol is a 20-carbon molecule with cyclohexenyl ring, a side chain with four double bonds (all in trans configuration) and an alcohol end group.

Applicazioni

Retinol has been used as a standard in ultra-performance liquid chromatography - tandem mass spectrometer (UPLC-MS/MS) for the vitamins detection and quantification.

Azioni biochim/fisiol

Retinol and its derivatives exhibit anti-aging properties. Retinol is used for treating wrinkles and signs of aging. However, due to its photo instability and skin irritation potency, it is hardly used in cosmetic formulations. Retinol is also used as a therapeutic for dermatoses. Its deficiency leads to xerosis and follicular hyperkeratosis.

Definizione di unità

1 U corresponds to 1 international U acc. to Ph Eur II, 217 (1983)

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H317,H319,H360FD,H413
• Consigli di prudenza: P202 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Aquatic Chronic 4 - Eye Irrit. 2 - Repr. 1B - Skin Sens. 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves