V8388

Vincristine sulfate

meets USP testing specifications

• Sinonimo/i: Vincristine sulfate salt, 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR
• Formula empirica (notazione di Hill): C₄₆H₅₆N₄O₁₀ · H₂SO₄
• Numero CAS: 2068-78-2
• Peso molecolare: 923.04
• Beilstein: 3924631
• Numero CE: 218-190-0
• Numero MDL: MFCD00084729
• Codice UNSPSC: 12352210
• ID PubChem: 24900771
• NACRES: NA.21

Proprietà

• agenzia: USP/NF; meets USP testing specifications
• Livello qualitativo: 200
• Solubilità: ethanol: slightly soluble; methanol: soluble; water: freely soluble
• Spettro attività antibiotica: neoplastics
• applicazioni: pharmaceutical (small molecule)
• Modalità d’azione: protein synthesis | interferes
• Temperatura di conservazione: −20°C
• Stringa SMILE: OS(O)(=O)=O.CC[C@]1(O)CC2CN(CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C=O)C7[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67C89)C(=O)OC)C1
• InChI: 1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1; AQTQHPDCURKLKT-PNYVAJAMSA-N

Descrizione

Descrizione generale

Vincristine sulfate is an alkaloid present in Cantharanthus roseus.[1]

Applicazioni

Vincristine sulfate has been used:

• as a positive control in potato disc anti-tumor bioassay[2]
• as a standard cytotoxic agent[3]
• to treat cells for manipulation of the microtubule network[4]

Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).

Azioni biochim/fisiol

Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.[1]

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H300,H341,H361fd
• Consigli di prudenza: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Classi di pericolo: Acute Tox. 2 Oral - Muta. 2 - Repr. 2
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)