SYNPLE-P004

Reagent-cartridge CRBN-PEG₄

Synple

• Sinonimo/i: Synple 2
• Numero MDL: MFCD32903606
• Codice UNSPSC: 12161503
• NACRES: NA.22

Proprietà

• ligand: pomalidomide
• Livello qualitativo: 100
• Parametri: up to 0.1 mmol scale
• Stringa SMILE: [s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C
• InChI: HVPZHRHEHKZOOJ-TYBLODHISA-N

Descrizione

Descrizione generale

Reagent-cartridge CRBN-PEG₄ is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG₄
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde

Cartridge contents:

• Reducing agent (supported cyanoborohydride)
• Base (supported triethylamine)
• SCX (for purification)
• Degrader building block linker reagent

Related Cartridges:

• SYNPLE-P001Reagent-cartridge CRBN-PEG₁
• SYNPLE-P002Reagent-cartridge CRBN-PEG₂
• SYNPLE-P003Reagent-cartridge CRBN-PEG₃
• SYNPLE-P005Reagent-cartridge CRBN-PEG₅
• SYNPLE-P021Reagent-cartridge VHL-PEG₁
• SYNPLE-P022Reagent-cartridge VHL-PEG₂
• SYNPLE-P023Reagent-cartridge VHL-PEG₃
• SYNPLE-P024Reagent-cartridge VHL-PEG₄
• SYNPLE-P025Reagent-cartridge VHL-PEG₅

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks

Features and Benefits of Synple Platform

• Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
• Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
• Safety - all chemicals are contained in the system, minimizing the user′s exposure
• Set-up reaction in less than 5 minutes
• Small footprint
• Plug & Play system - simple installation
• Reaction temperatures from 25 °C - 80 °C
• Cartridges available for many different reactions
• Prefilled with all required reagents
• RFID chip containing optimized reaction protocol

Altre note

An integrated console for capsule-based, automated organic synthesis

Note legali

Product of Synple Chem AG

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319
• Consigli di prudenza: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable