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H2910

Sigma-Aldrich

Hydrochlorothiazide

meets USP testing specifications

Sinonimo/i:

6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, 6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

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About This Item

Formula empirica (notazione di Hill):
C7H8ClN3O4S2
Numero CAS:
58-93-5
Peso molecolare:
297.74
Numero CE:
200-403-3
Numero MDL:
MFCD00051765
Codice UNSPSC:
12352125
ID PubChem:
24895542
NACRES:
NA.21

agenzia

USP/NF
meets USP testing specifications

Livello qualitativo

200

Forma fisica

solid

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl

InChI

1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
JZUFKLXOESDKRF-UHFFFAOYSA-N

Informazioni sul gene

human ... ALB(213) , CA1(759) , CA2(760) , CA4(762) , SLC12A3(6559)

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Azioni biochim/fisiol

Carbonic anhydrase inhibitor

Pittogrammi

Health hazard
GHS08

Avvertenze

Warning

Indicazioni di pericolo

H351

Classi di pericolo

Carc. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
WXBD2727V
SLBZ7352
SLBR7387V
SLBQ2575V
SLBH6369V

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Lancet (London, England), 1(8421), 123-126 (1985-01-19)
14 hypertensive men with type II diabetes sequentially received, in random order, hydrochlorothiazide 50 mg twice a day, propranolol 80 mg twice a day, and both drugs in combination. The 3-week treatment periods were separated by a 1-week washout period.
Irfan A Dhalla et al.
Annals of internal medicine, 158(6), 447-455 (2013-04-05)
Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension. To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults. Propensity score-matched observational cohort study with up to 5 years of follow-up.
Franz H Messerli et al.
The American journal of medicine, 124(10), 896-899 (2011-10-04)
Hydrochlorothiazide (HCTZ) has become by far the most commonly prescribed antihypertensive drug in the US. In 2008, 47.8 million prescriptions were written for HCTZ alone and 87.1 million prescriptions for HCTZ combinations. However, there is no evidence that HCTZ in
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Hypertension (Dallas, Tex. : 1979), 59(6), 1110-1117 (2012-04-25)
Hydrochlorothiazide (HCTZ) is widely used for hypertension, and prescriptions for HCTZ outnumber those for chlorthalidone (CTDN) by >20-fold in 2 recent surveys. Some have recently expressed a preference for CTDN. However, head-to-head trials testing the effect of the 2 drugs
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