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91801

Supelco

Cynarin

analytical standard

Sinonimo/i:

1,3-Dicaffeoylquinic acid, (1R,3R,4S,5R)-1,3-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-4,5-dihydroxycyclohexanecarboxylic acid, 1,5-DQA, 1,5-Dicaffeoylquinic acid, Cynarin, Cynarine

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About This Item

Formula empirica (notazione di Hill):
C25H24O12
Numero CAS:
Peso molecolare:
516.45
Numero MDL:
Codice UNSPSC:
85151701
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥98.0% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Impurezze

≤10.0% water

applicazioni

food and beverages

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

O[C@@H]1C[C@](C[C@@H](OC(=O)\C=C\c2ccc(O)c(O)c2)[C@H]1O)(OC(=O)\C=C\c3ccc(O)c(O)c3)C(O)=O

InChI

1S/C25H24O12/c26-15-5-1-13(9-17(15)28)3-7-21(31)36-20-12-25(24(34)35,11-19(30)23(20)33)37-22(32)8-4-14-2-6-16(27)18(29)10-14/h1-10,19-20,23,26-30,33H,11-12H2,(H,34,35)/b7-3+,8-4+/t19-,20-,23+,25-/m1/s1
YDDUMTOHNYZQPO-RVXRWRFUSA-N

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Descrizione generale

Cynarin is an active constituent of artichoke plant, exhibiting choleretic and hypocholesterolemic activities. It is also widely used in phytoterapic preparations with special indication in hepatic affections.

Applicazioni

Cynarin may be used as an analytical reference standard for the quantification of the analyte in plasma samples using high-performance liquid chromatography technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Phenolic compound found in artichoke. Antioxidant and choleretic properties. Potential immunosuppressive agent.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

This compound is commonly found in plants of the genus: arnica echinacea

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Chicoric Acid ≥95% (HPLC)

Sigma-Aldrich

C7243

Chicoric Acid

3,4-Dicaffeoylquinic acid phyproof® Reference Substance

PHL80425

3,4-Dicaffeoylquinic acid

Chlorogenic acid European Pharmacopoeia (EP) Reference Standard

Y0000569

Chlorogenic acid

Validated HPLC method for cynarin determination in biological samples
Alonso RM, et al.
Acta Acad. Med. Sin., 25(2), 267-267 (2006)
Guo-Chung Dong et al.
Journal of medicinal chemistry, 49(6), 1845-1854 (2006-03-17)
AFTIR (after flowing through immobilized receptor) is a novel method for screening herbal extracts for pharmaceutical properties. Using AFTIR, we identified Cynarin in Echinacea purpurea by its selective binding to chip immobilized CD28, a receptor of T-cells, which is instrumental
Esra Erikel et al.
Journal of ethnopharmacology, 237, 171-181 (2019-03-21)
Cynarin is an artichoke phytochemical that possesses a variety of pharmacological features including free-radical scavenging and antioxidant activity. The origin of artichoke species appears to be Mediterranean region. Two of these species, globe artichoke (Cynara cardunculus var. scolymus L.) and
Yi Wang et al.
Bioorganic & medicinal chemistry letters, 21(23), 7064-7067 (2011-10-22)
The complex and highly impermeable cell wall of Mycobacterium tuberculosis (Mtb) is largely responsible for the ability of the mycobacterium to resist the action of chemical therapeutics. An L-rhamnosyl residue, which occupies an important anchoring position in the Mtb cell
Bianca Sperl et al.
Bioorganic & medicinal chemistry letters, 19(12), 3305-3309 (2009-05-12)
In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein-protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover

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