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Merck
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12070

Sigma-Aldrich

Benzamide

purum, ≥98.0% (HPLC)

Sinonimo/i:

Benzoic acid amide

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About This Item

Formula condensata:
C6H5CONH2
Numero CAS:
55-21-0
Peso molecolare:
121.14
Beilstein:
385876
Numero CE:
200-227-7
Numero MDL:
MFCD00007968
Codice UNSPSC:
12352100
ID PubChem:
329749611

Grado

purum

Saggio

≥98.0% (HPLC)

Punto di fusione

125-128 °C (lit.)
125-128 °C

Solubilità

methanol: soluble 1 g/10 mL, clear, colorless to faintly yellow

Stringa SMILE

NC(=O)c1ccccc1

InChI

1S/C7H7NO/c8-7(9)6-4-2-1-3-5-6/h1-5H,(H2,8,9)
KXDAEFPNCMNJSK-UHFFFAOYSA-N

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Applicazioni

Benzamide was used to study the effect of inhibitors of endonuclease and poly(ADP ribose) polymerase on anti-Fas monoclonal antibody treated Jurkat cells.

Azioni biochim/fisiol

Benzamide is a specific inhibitor of poly(ADP-ribose)polymerase. It prevents glutamate- and methamphetamine-induced neurotoxicity in vitro in C57B1/6N mouse.
Inhibits poly(ADP-ribose) polymerase (PARP).

Sostituito da

N° Catalogo
Descrizione
Determinazione del prezzo

135828

Benzamide, 99%

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H341

Classi di pericolo

Acute Tox. 4 Oral - Muta. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

356.0 °F - closed cup

Punto d’infiammabilità (°C)

180 °C - closed cup

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
441182/1
1141565
450238/1
1325570
393736/1

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I Yamadori et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46(1), 85-90 (1997-12-24)
We compared two methods to stain apoptotic cells, one using terminal deoxynucleotidyl transferase (TDT), the other DNA polymerase I, using leukemia cell lines treated with anti-Fas monoclonal antibody (MAb). Both TDT and polymerase I strongly reacted with fragmented nuclei of
E Kun et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(23), 7219-7223 (1983-12-01)
Human fibroblasts were subjected to nutritionally induced G1 block, followed by release and subsequent entry into S phase, and exposed to nontoxic concentrations of carcinogens in early S phase. Cell transformation occurred as determined by early morphologic cell alterations, anchorage-independent
C Cosi et al.
Brain research, 735(2), 343-348 (1996-10-07)
Previous studies have indicated that the activation of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA plasticity-related phenomena, is an early event occurring in glutamate-induced neurotoxicity in vitro, and that inhibitors of PARP, including benzamide, are protective against both glutamate-
James M Wright et al.
The Cochrane database of systematic reviews, 4, CD001841-CD001841 (2018-04-19)
This is the first update of a review published in 2009. Sustained moderate to severe elevations in resting blood pressure leads to a critically important clinical question: What class of drug to use first-line? This review attempted to answer that
A P de Jong et al.
Journal of chromatography, 419, 233-242 (1987-08-07)
A universal rapid, sensitive and selective high-performance liquid chromatographic method with UV detection at 230 nm has been developed for the determination of benzamide drugs in human plasma and urine. Sample pretreatment is carried out using solid-phase extraction columns, resulting
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